A0A384BKM2 · A0A384BKM2_URSMA

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchylomicron
Cellular Componenthigh-density lipoprotein particle
Cellular Componentintermediate-density lipoprotein particle
Cellular Componentmultivesicular body
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionamyloid-beta binding
Molecular Functionheparin binding
Molecular Functionlipid binding
Molecular Functionlow-density lipoprotein particle receptor binding
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Molecular Functionvery-low-density lipoprotein particle receptor binding
Biological Processcholesterol catabolic process
Biological Processlipid transport
Biological Processlipoprotein catabolic process
Biological Processnegative regulation of neuron apoptotic process
Biological Processpositive regulation of nitric-oxide synthase activity
Biological Processregulation of amyloid-beta clearance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apolipoprotein E

Gene names

    • Name
      APOE

Organism names

Accessions

  • Primary accession
    A0A384BKM2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_504270439519-323Apolipoprotein E

Interaction

Subunit

Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region21-46Disordered
Compositional bias22-40Basic and acidic residues
Domain230-323PpiC
Coiled coil246-284

Sequence similarities

Belongs to the apolipoprotein A1/A4/E family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    37,253
  • Last updated
    2022-08-03 v2
  • Checksum
    C15F34368C62FCE6
MKVLWAALVVALLAGCWADMEPEPKPEAETKLEGESKLEPEAGRQTGQPWELALARFWDYLRWVQTMSEQVQEDVLSNRVIQELTTLMEETLKEVKMYTEEVEEQLGPLTSEMQARVTKELQAAQARLRSDMEDVRSRLTQYRGELQAMLGQSSDELRARLTSHLRKLRKRLLRDAEDLQKRLAVYRAGVREGTERSMDTITQHLWPLVMHVRTRQAIARSEGALPLRERAEALGQHLRGQLEEVGSRARSQLEEVREQVEVMRAKLEEQAEQMRQQAEAFQARLRSWFEPLVEDMQRQWAELVEKVQAAVGTGPTTAPVETQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias22-40Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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