A0A384BKM2 · A0A384BKM2_URSMA
- ProteinApolipoprotein E
- GeneAPOE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids323 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chylomicron | |
Cellular Component | high-density lipoprotein particle | |
Cellular Component | intermediate-density lipoprotein particle | |
Cellular Component | multivesicular body | |
Cellular Component | very-low-density lipoprotein particle | |
Molecular Function | amyloid-beta binding | |
Molecular Function | heparin binding | |
Molecular Function | lipid binding | |
Molecular Function | low-density lipoprotein particle receptor binding | |
Molecular Function | peptidyl-prolyl cis-trans isomerase activity | |
Molecular Function | very-low-density lipoprotein particle receptor binding | |
Biological Process | cholesterol catabolic process | |
Biological Process | lipid transport | |
Biological Process | lipoprotein catabolic process | |
Biological Process | negative regulation of neuron apoptotic process | |
Biological Process | positive regulation of nitric-oxide synthase activity | |
Biological Process | regulation of amyloid-beta clearance |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameApolipoprotein E
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A384BKM2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MKVLWAALVVALLAGCWA | ||||||
Chain | PRO_5042704395 | 19-323 | Apolipoprotein E | |||
Sequence: DMEPEPKPEAETKLEGESKLEPEAGRQTGQPWELALARFWDYLRWVQTMSEQVQEDVLSNRVIQELTTLMEETLKEVKMYTEEVEEQLGPLTSEMQARVTKELQAAQARLRSDMEDVRSRLTQYRGELQAMLGQSSDELRARLTSHLRKLRKRLLRDAEDLQKRLAVYRAGVREGTERSMDTITQHLWPLVMHVRTRQAIARSEGALPLRERAEALGQHLRGQLEEVGSRARSQLEEVREQVEVMRAKLEEQAEQMRQQAEAFQARLRSWFEPLVEDMQRQWAELVEKVQAAVGTGPTTAPVETQ |
Interaction
Subunit
Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 21-46 | Disordered | ||||
Sequence: EPEPKPEAETKLEGESKLEPEAGRQT | ||||||
Compositional bias | 22-40 | Basic and acidic residues | ||||
Sequence: PEPKPEAETKLEGESKLEP | ||||||
Domain | 230-323 | PpiC | ||||
Sequence: RAEALGQHLRGQLEEVGSRARSQLEEVREQVEVMRAKLEEQAEQMRQQAEAFQARLRSWFEPLVEDMQRQWAELVEKVQAAVGTGPTTAPVETQ | ||||||
Coiled coil | 246-284 | |||||
Sequence: GSRARSQLEEVREQVEVMRAKLEEQAEQMRQQAEAFQAR |
Sequence similarities
Belongs to the apolipoprotein A1/A4/E family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length323
- Mass (Da)37,253
- Last updated2022-08-03 v2
- ChecksumC15F34368C62FCE6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 22-40 | Basic and acidic residues | ||||
Sequence: PEPKPEAETKLEGESKLEP |
Keywords
- Technical term