A0A380G708 · A0A380G708_STAIN
- ProteinDelta-aminolevulinic acid dehydratase
- GenehemB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 118 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 120 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 128 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 195 | Schiff-base intermediate with substrate | |||
Binding site | 205 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 217 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 233 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 248 | Schiff-base intermediate with substrate | |||
Binding site | 274 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
Binding site | 313 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | porphobilinogen synthase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus > Staphylococcus intermedius group
Accessions
- Primary accessionA0A380G708
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)36,594
- Last updated2018-11-07 v1
- MD5 ChecksumD271CE85F50DECA17719E0665A29F73C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
UHDP01000003 EMBL· GenBank· DDBJ | SUM46532.1 EMBL· GenBank· DDBJ | Genomic DNA |