A0A380G708 · A0A380G708_STAIN

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

132550100150200250300
Type
IDPosition(s)Description
Binding site118Zn2+ (UniProtKB | ChEBI); catalytic
Binding site120Zn2+ (UniProtKB | ChEBI); catalytic
Binding site128Zn2+ (UniProtKB | ChEBI); catalytic
Active site195Schiff-base intermediate with substrate
Binding site2055-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2175-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site233Mg2+ (UniProtKB | ChEBI)
Active site248Schiff-base intermediate with substrate
Binding site2745-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3135-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionporphobilinogen synthase activity
Molecular Functionzinc ion binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • Name
      hemB
    • ORF names
      NCTC11048_01588

Organism names

  • Taxonomic identifier
  • Strain
    • NCTC 11048
  • Taxonomic lineage
    Bacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus > Staphylococcus intermedius group

Accessions

  • Primary accession
    A0A380G708

Proteomes

Subcellular Location

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    325
  • Mass (Da)
    36,594
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    D271CE85F50DECA17719E0665A29F73C
MKFDRHRRLRSSKVMRDMVRETHVRKEDLIYPIFVVEKDDVKTEIKSLPGVYQISLNLLHEELKAAYDLGIRAIMFFGIPNEKDACGTGAFIDDGIIQKATRLAKSMYDDLLILADTCLCEYTDHGHCGVIDPHTHDVDNDQTLPFLVQTAISQVKAGADIIAPSNMMDGFVAAIREGLDEAGYYHIPIMSYGIKYASSFFGPFRDAAESAPSFGDRKTYQMDPANRLEALRELESDLNEGADMMIVKPALSYLDIIRDVRNNSNIPIIAYNVSGEYSMTKAAALNGWIDEEKVVMEQMVSMKRAGADMIITYFAKDICQYLDQQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UHDP01000003
EMBL· GenBank· DDBJ
SUM46532.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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