A0A380G3I6 · A0A380G3I6_STAIN

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site116NAD+ (UniProtKB | ChEBI)
Binding site177NAD+ (UniProtKB | ChEBI)
Binding site200NAD+ (UniProtKB | ChEBI)
Binding site223substrate
Binding site245Zn2+ (UniProtKB | ChEBI)
Binding site245substrate
Binding site248Zn2+ (UniProtKB | ChEBI)
Binding site248substrate
Active site313Proton acceptor
Active site314Proton acceptor
Binding site314substrate
Binding site347Zn2+ (UniProtKB | ChEBI)
Binding site347substrate
Binding site401substrate
Binding site406Zn2+ (UniProtKB | ChEBI)
Binding site406substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • ORF names
      NCTC11048_00712

Organism names

Accessions

  • Primary accession
    A0A380G3I6

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    46,847
  • Last updated
    2018-11-07 v1
  • Checksum
    D4A6EB4024C4D72D
MIVNSQTFLQQFETTETFNPEIHAQVTAICDRVQREGDRALLDYNEQFDGVTVETLEVPQADIEAAYYHIDEDLRHALEHSFQRIRDYQTQIKYENQYATPELYEVYHPIERVGIYVPGGKASYPSTVLMTATLAKVAGVKNISVVTPPQPNGIASSVLAACHIVGVDHVYQVGGAQSIAALAYGTETIPKVDKIVGPGNQYVAYAKKALYGEVGIDQIAGPSEIALIIDDTCDLDAIVYDVFAQAEHDEMARTFVISTDLALLESLETRIQEFLKDAPRYDILKVSLTEHHYLIHATDFEDSCRVMNTIAPEHASIQTAQPEDYLPHIYYVGSLFLGGYAPEAIGDYIAGPSHVLPTQRTARFQHGLSVNDFLTKHTVIHLSQSTYEKTYRDAARIAQDEQLYHHQKSLEIRQRGDDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UHDP01000003
EMBL· GenBank· DDBJ
SUM45724.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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