A0A380G3I6 · A0A380G3I6_STAIN
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids419 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 116 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 177 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 200 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 223 | substrate | ||||
Sequence: S | ||||||
Binding site | 245 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 245 | substrate | ||||
Sequence: Q | ||||||
Binding site | 248 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 248 | substrate | ||||
Sequence: H | ||||||
Active site | 313 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 314 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 314 | substrate | ||||
Sequence: H | ||||||
Binding site | 347 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 347 | substrate | ||||
Sequence: D | ||||||
Binding site | 401 | substrate | ||||
Sequence: E | ||||||
Binding site | 406 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 406 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus > Staphylococcus intermedius group
Accessions
- Primary accessionA0A380G3I6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length419
- Mass (Da)46,847
- Last updated2018-11-07 v1
- ChecksumD4A6EB4024C4D72D