A0A377M0M8 · A0A377M0M8_ENTCL

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site59-61substrate
Binding site90-93substrate; in site B
Binding site100-102substrate
Binding site148substrate
Active site149Proton donor/acceptor
Active site279
Binding site280substrate
Binding site285-287substrate
Site292Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      NCTC10005_05070

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC10005
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    A0A377M0M8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-303Fumarate lyase N-terminal
Domain369-421Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    45,377
  • Last updated
    2018-11-07 v1
  • Checksum
    F66052F96A6FD60C
MPVSLIQALALTKRAAAKVNLDLGLLAADKANAIISAADEVLAGKHPDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAAVIAIREQLIPQLNVLKSTLNEKAQAFSDIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHLSELALGGTAVGTGLNTHPEYAVRVAEELAAITGQPFVTAPNKFEALATCDALVHTHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCCQVLGNDVAVNMGGASGNFELNVYRPMVIHNVLQSVRLLADGMESFNAHCASGIEPNRERISQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKASALALGYLTEDEFDAWVRPEAMVGSLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UGJB01000004
EMBL· GenBank· DDBJ
STQ12285.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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