A0A374N6B3 · A0A374N6B3_9FIRM

  • Protein
    Endolytic murein transglycosylase
  • Gene
    mltG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • a peptidoglycan chain = a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end.
    EC:4.2.2.29 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site.

145150100150200250300350400450
TypeIDPosition(s)Description
Site330Important for catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionlytic endotransglycosylase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endolytic murein transglycosylase
  • EC number
  • Alternative names
    • Peptidoglycan lytic transglycosylase
    • Peptidoglycan polymerization terminase

Gene names

    • Name
      mltG
    • ORF names
      DW802_02100
      , DW960_04220
      , DWY59_02275
      , DXA25_01525
      , DXD83_03115

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • AF25-7LB
    • AM32-13AC
    • AM46-2BH
    • CF01-14
    • TM09-18AC
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Oscillospiraceae > Ruminococcus

Accessions

  • Primary accession
    A0A374N6B3

Proteomes

Subcellular Location

Cell membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane92-111Helical

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region35-73Disordered
Compositional bias43-57Polar residues
Compositional bias58-73Basic and acidic residues

Sequence similarities

Belongs to the transglycosylase MltG family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    51,895
  • Last updated
    2018-11-07 v1
  • Checksum
    4C57752D97ABEA56
MNPDNFNMSEQELNAQRRRRAENFKLNIDESEYEDDNFVKSEDEPSNLNSYSGQDVKKQMARESKQVLKQKKKEEKKALKAKNKYNRRTFRFIWIISVLIVGAMAAVYMITGMNDLLAVNRTDSSTVKIEIPENPTVDDVTKVLVDNKVIGEPSYFKLFVNVTKSADDFTQGTYEIRRNMDYEAIINFLSSNNNRTDTVSVTITEGESVLEIANTLEKNGALGDRDEFLSLCNSEKFDSDFDFIKAETNADKRYYKLEGYLYPDTYEFYRNENAESVIYKFLNNYETKINEKQTVDGYSKKTTVLKMVEESDTKYSLDQVMTIASIIQAEAADKEDMYYISSILHNRLTADSSLGVSSLGLDSTKFYPYRSLEDVPENDRSTYKSRYDTYDRKGLPYGPICNPGMDAIIAALNPNSSDYYFFCHDSKGQAYYASTLEQQNANLEYIESYDN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias43-57Polar residues
Compositional bias58-73Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QSOJ01000001
EMBL· GenBank· DDBJ
RGI82946.1
EMBL· GenBank· DDBJ
Genomic DNA
QRUA01000002
EMBL· GenBank· DDBJ
RGR24986.1
EMBL· GenBank· DDBJ
Genomic DNA
QSDI01000001
EMBL· GenBank· DDBJ
RGY73754.1
EMBL· GenBank· DDBJ
Genomic DNA
QSEV01000002
EMBL· GenBank· DDBJ
RGZ97695.1
EMBL· GenBank· DDBJ
Genomic DNA
QSIY01000001
EMBL· GenBank· DDBJ
RHD24318.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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