A0A371KAV2 · A0A371KAV2_9EURY
- ProteinPolyamine aminopropyltransferase
- GenespeE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids608 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity
- S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H+
Pathway
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 331 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 374 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 400 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 418 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 452-453 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Active site | 470 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | spermidine synthase activity | |
Biological Process | spermidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyamine aminopropyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionA0A371KAV2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-29 | Helical | |||
Transmembrane | 41-62 | Helical | |||
Transmembrane | 74-96 | Helical | |||
Transmembrane | 108-128 | Helical | |||
Transmembrane | 182-201 | Helical | |||
Transmembrane | 207-228 | Helical | |||
Transmembrane | 274-291 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Homodimer or homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length608
- Mass (Da)66,692
- Last updated2018-11-07 v1
- MD5 ChecksumF5B31E2C2D0ABC49EFAF566838BC60E2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QEQI01000003 EMBL· GenBank· DDBJ | RDZ31083.1 EMBL· GenBank· DDBJ | Genomic DNA |