A0A370P3Q0 · A0A370P3Q0_ASPPH

Function

function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Features

Showing features for active site, binding site.

143650100150200250300350400
TypeIDPosition(s)Description
Active site192Nucleophile
Binding site192Mg2+ 1 (UniProtKB | ChEBI)
Active site194Proton donor/acceptor
Binding site194Mg2+ 1 (UniProtKB | ChEBI)
Binding site201alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site306alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site317alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site324alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site362alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site364alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site398Mg2+ 1 (UniProtKB | ChEBI)
Binding site410Mg2+ 1 (UniProtKB | ChEBI)
Binding site412Mg2+ 1 (UniProtKB | ChEBI)
Binding site415Mg2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process
Biological Processmannose metabolic process
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number

Gene names

    • ORF names
      M752DRAFT_226143

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 13157
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus

Accessions

  • Primary accession
    A0A370P3Q0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-29Disordered
Domain1-55J
Compositional bias9-29Basic and acidic residues

Sequence similarities

Belongs to the eukaryotic PMM family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    436
  • Mass (Da)
    48,940
  • Last updated
    2018-11-07 v1
  • Checksum
    0C33F9E92555E373
MLSSEPCRESLKSHPDRVPVDSPERAARTRKFQEISDAYYTLSDVSRRREYDAMRMAGGVEEEEEEVPRGGAGGFPWSAFGFGTADSEQRASEQFGSVFEEMLREEGLASEGTDADGQTRSHPTSRFWSVIANAPGALAGAVAGNRLGAVRDAKGKSVYDVFLQLPQTDRARLLSELAAKDRPLKGTICLFDVDKTLTPARANVTPEMLTLLSQLRHKCAIGFVGGSNLPKQQEQLGRNTTDVTTLFDFCFAENGLTAFRLGKPLRSNSFIQWLGEEKYQKLVNFLLKYIANLEIPKKRGTFVEFRNGMINVSPIGRNASTEERKEFEAYDKIHNIRRDLVDALKKEFPDYGLSYSIGGEISFDVFPTGWDKTYCLQHVEAEKDITGIDYKTIHFFGDKTFPGGNDYEIYSDPRTIGHSVEDPDDTMRQLRELFQL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias9-29Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ851880
EMBL· GenBank· DDBJ
RDK36499.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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