A0A370NW46 · A0A370NW46_9BURK

  • Protein
    Isocitrate dehydrogenase kinase/phosphatase
  • Gene
    aceK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site328-334ATP (UniProtKB | ChEBI)
Binding site349ATP (UniProtKB | ChEBI)
Active site384

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function[isocitrate dehydrogenase (NADP+)] kinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionphosphoprotein phosphatase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processglucose metabolic process
Biological Processglyoxylate cycle
Biological Processpeptidyl-serine phosphorylation
Biological Processprotein dephosphorylation
Biological Processregulation of catalytic activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase kinase/phosphatase
  • EC number
  • Short names
    IDH kinase/phosphatase
    ; IDHK/P

Gene names

    • Name
      aceK
    • ORF names
      DN412_13315

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S23
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Cupriavidus

Accessions

  • Primary accession
    A0A370NW46

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-322Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Domain323-582Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase

Sequence similarities

Belongs to the AceK family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    71,565
  • Last updated
    2018-11-07 v1
  • Checksum
    A2200EF4A86FD435
MSHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSHQAKLKFEAGDWHGLQQIQRDRIAFYNERVRESSVILEDEYDAKNIEDEIWQQIKLHYIGLLTNHHQPELAETFFNSVCTRILHRSYFNNDFIFVRPAISTEYIENEESPTRPTFRAYYPGSREGMAACFERVVHNFQLERPFEDLQRDIGYVVRAVSEHFGDLRIAPNFQVHTLSSLFFRNKSAYIIGRILNGDRTFPLAIPILHGPGGKLTLDTVLLEKEQLLILFSFTHSYFMVDMEIPSAYVTFLRDIMPRKPRAEIYTSLGLQKQGKNLFYRDFLHHLQHSSDKFIVAPGIRGLVMLVFTLPSYPYVFKVIRDFFPAPKETTRELVKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDDALVREFEQHAPSMIEYQRGKQGGEEIVVRHVYIERRMTPLNIYLTEGSDAQVEHGVMEYGNTVKELIAANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNIRHVPQPRNEEEEMSGEVWYTVRPHDIFPETYRTFLLGDPRVRAAFLRHHADFFDPAMWQSHKDRLLAGHVHDFFAYHSSQRFIHRYGEHGAEPTAVSKPGPERRVA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QKWJ01000013
EMBL· GenBank· DDBJ
RDK09825.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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