A0A370NFU4 · A0A370NFU4_9BURK

  • Protein
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Gene
    dut
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site67-69substrate
Binding site80substrate
Binding site84-86substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      DLM46_00920

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S27
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia

Accessions

  • Primary accession
    A0A370NFU4

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-146dUTPase-like

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    148
  • Mass (Da)
    15,623
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    B759F1B32012D6B57FFB57DCCBA4F7D0
MKLDLKILDARMRDQLPAYATTGSAGLDLRACLDEALTLAPGDTALVPTGLAIHVGDPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGETTFVLNPMERLAQLVIVPVVQAAFNIVDDFAESERGAGGFGSTGKH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QHKS01000001
EMBL· GenBank· DDBJ
RDK04469.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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