A0A370N552 · A0A370N552_9BURK

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site56Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site74Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site122Proton donor/acceptor
Binding site122Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding
Biological Processmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    lactoylglutathione lyase
  • EC number
  • Alternative names
    • Aldoketomutase
    • Glyoxalase I
    • Ketone-aldehyde mutase
    • Methylglyoxalase
    • S-D-lactoylglutathione methylglyoxal lyase

Gene names

    • Name
      gloA
    • ORF names
      DLM46_21695

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S27
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia

Accessions

  • Primary accession
    A0A370N552

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-126VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    128
  • Mass (Da)
    14,415
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    F27050095F204012D01B540F9359B2F1
MRLLHTMLRVGDLDRSIVFYTELLGMKLLRREDYPDGKFTLAFVGYEDERNGTVIELTHNWDTPSYDLGTGFGHLAVEVEDAYAACDKIKAQGGTVVREAGPMKHGTTVIAFVTDPDGYKIEFIQKKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QHKS01000014
EMBL· GenBank· DDBJ
RDK00598.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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