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A0A369M4D2 · A0A369M4D2_9ACTN

  • Protein
    Alkyl hydroperoxide reductase C
  • Gene
    ahpC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

118720406080100120140160180
TypeIDPosition(s)Description
Active site47Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADH-dependent peroxiredoxin activity
Molecular Functionthioredoxin peroxidase activity
Biological Processcell redox homeostasis
Biological Processcellular response to stress
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alkyl hydroperoxide reductase C
  • EC number
  • Alternative names
    • Peroxiredoxin
    • Thioredoxin peroxidase

Gene names

    • Name
      ahpC
    • ORF names
      C1877_03630

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 3C
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Eggerthellales > Eggerthellaceae > Gordonibacter

Accessions

  • Primary accession
    A0A369M4D2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.

Family & Domains

Sequence similarities

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    187
  • Mass (Da)
    20,955
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    D25EC2001E6B9436D41F2294BBA7A6CB
MSMINREIDDFSVQAFCQDEFATVTKDDVLGHWSVFFFYPADFTFVCPTELEDLAALYDQFKAADCEIYSVSCDTHFAHKAWHDASENIKNLPYPMLADPTHKLADIFDVYIEDEGVAERGSFIVNPEGRIVCYEVNAGNIGRNAAELLRRVQASQFVAEHGDSVCPARWVPGSEVLHPGIDLVGKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PPTS01000002
EMBL· GenBank· DDBJ
RDB66292.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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