A0A368THB7 · A0A368THB7_UNCME

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site100substrate
Binding site235-237substrate
Binding site244Mn2+ (UniProtKB | ChEBI)
Binding site263Mn2+ (UniProtKB | ChEBI)
Binding site285substrate
Active site287
Binding site304Mn2+ (UniProtKB | ChEBI)
Binding site400-402substrate
Binding site402GTP (UniProtKB | ChEBI)
Binding site433GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      C5S53_08295

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CONS3730B06UFb1
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanophagales

Accessions

  • Primary accession
    A0A368THB7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-254Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain259-620Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    640
  • Mass (Da)
    72,470
  • Last updated
    2018-11-07 v1
  • Checksum
    71E5E984C85215BA
MKTKEEKRSEKVEDERTIGMLKARLGEENYQKLITIDNPKLHQFVAKYIELCNPDKIFVCSDSPEDLMYVRRETIKAGEEEELTIDGHTVHFDGYYDQARDKANSKFLLPSGVELGPNINAMDREDGLKEIHPIMKDIMQGHQLYVRFFCLGPLNSQFAIPAVQLTDSGYVAHSEDLLYRQGYDEFVRLGRSARFLKFVHSAGELDARKTSKNIDKRRVYIDLEDETVYSMNTQYGGNTIGLKKLAMRPAITRASKEGWLTEHMFIMGVHGPFGRVTYFTGAFPSLCGKTSTAMLPGETIVGDDIAYLRDIDGVIHAVNPENGIFGIIQGVNSVDDPQIWNALHSPGEVIFSNVLITEEKGVHWIGKDEEEPERGIHHSGEWTPGKRDEDDNLISLSHPNARFTLDMRLLENVDPELNNPKGVLVGGIIYGGRDTDTKVPVEESFDWTHGVITMGAALESETTAATLGKEGVRKINPMSNLDFLSIPIGRYIESHLDFGAKLNNPAPIFSVNYFLSDAKGNFTNAKTDKAVWLKWIELRSHHEVEAIKTPTGFIPRYEDLKKLFQEVLKKDYSEKDYITQFSVRVAESLAKIERVKEFYKTKVYDTPQIVFDVLEEQGQRLIQAREKYGDPIPPLKLKLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QENH01000158
EMBL· GenBank· DDBJ
RCV64522.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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