A0A367E694 · A0A367E694_9ACTN

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78-81substrate
Binding site100substrate
Binding site101Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      DQ392_32930

Organism names

  • Taxonomic identifier
  • Strain
    • LHW50302
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A367E694

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    163
  • Mass (Da)
    16,875
  • Last updated
    2018-11-07 v1
  • Checksum
    33FDD04C3B8DF7B4
MHTTPVPTADLADQYGDRLRVCSLQFTGYGAVRSFAGPVRTVSCREDNALLHELLHMPGGGAVVVVDGGGSLATTLFGARMATRARDNGWAGVIVHGAVRDSASLSATRLGVQALGTNPRRAGKAGRGEVDVPVTFGGVSFGVGDILHADEDGVVLLPVDHLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QOIM01000057
EMBL· GenBank· DDBJ
RCG13302.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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