A0A366R2X6 · A0A366R2X6_9HYPO

  • Protein
    Uridylate kinase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40-45ATP (UniProtKB | ChEBI)
Binding site66a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site88-90a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site121-124a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site128a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site159ATP (UniProtKB | ChEBI)
Binding site165a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site176a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site204ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • ATP:UMP phosphotransferase
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • ORF names
      FIESC28_08966

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FIESC_28
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium incarnatum-equiseti species complex

Accessions

  • Primary accession
    A0A366R2X6

Proteomes

Subcellular Location

Cytoplasm
Nucleus
Note: Predominantly cytoplasmic.

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered
Region60-90NMPbind
Region158-168LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    24,581
  • Last updated
    2018-11-07 v1
  • Checksum
    70058597DB56D01C
MPAVPQDAPESAGQIPAPQKSTPTFNPEDVTVIFVLGGPGAGKGTQCSKLVSEHGFTHLSAGDLLRAEQERPGSQYGDLIKDYIRNGLIVPMEVTIALLENAMAAVLKETGSQKGRFLIDGFPRKMDQAVKFEETVCPAKLVLFFDCPEAVMESRLLERGKTSGREDDNADSIRKRFRTFIETSMPVVNHFEEVGKVLKLDATPTPDEVYANTEKALAERLGPSF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QKXC01000214
EMBL· GenBank· DDBJ
RBR11504.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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