A0A365TLG6 · A0A365TLG6_9GAMM
- ProteinSuccinate--CoA ligase [ADP-forming] subunit beta
- GenesucC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids388 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
- GTP + succinate + CoA = succinyl-CoA + GDP + phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | ATP (UniProtKB | ChEBI) | |||
Binding site | 53-55 | ATP (UniProtKB | ChEBI) | |||
Binding site | 99 | ATP (UniProtKB | ChEBI) | |||
Binding site | 102 | ATP (UniProtKB | ChEBI) | |||
Binding site | 107 | ATP (UniProtKB | ChEBI) | |||
Binding site | 199 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 213 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 264 | substrate; ligand shared with subunit alpha | |||
Binding site | 321-323 | substrate; ligand shared with subunit alpha | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | succinate-CoA ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | succinate-CoA ligase (GDP-forming) activity | |
Biological Process | succinyl-CoA metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit beta
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Vreelandella
Accessions
- Primary accessionA0A365TLG6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer of two alpha and two beta subunits.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length388
- Mass (Da)41,341
- Last updated2018-11-07 v1
- MD5 Checksum2EA9B4C522B7C1C53E6FF33C6778D211
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QNTU01000009 EMBL· GenBank· DDBJ | RBI66493.1 EMBL· GenBank· DDBJ | Genomic DNA |