A0A365PS77 · A0A365PS77_9GAMM

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-16NAD+ (UniProtKB | ChEBI)
Binding site14NADPH (UniProtKB | ChEBI)
Binding site15NADPH (UniProtKB | ChEBI)
Binding site35NADPH (UniProtKB | ChEBI)
Binding site52NADPH (UniProtKB | ChEBI)
Binding site108NADPH (UniProtKB | ChEBI)
Binding site108sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site108substrate
Binding site136sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site140NAD+ (UniProtKB | ChEBI)
Binding site140NADPH (UniProtKB | ChEBI)
Active site191Proton acceptor
Binding site191sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site244sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255NAD+ (UniProtKB | ChEBI)
Binding site255NADPH (UniProtKB | ChEBI)
Binding site255sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255-256substrate
Binding site256sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site279NADPH (UniProtKB | ChEBI)
Binding site281NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      DQ403_16470

Organism names

  • Taxonomic identifier
  • Strain
    • SST2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Stutzerimonas

Accessions

  • Primary accession
    A0A365PS77

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-160Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain180-320Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    36,282
  • Last updated
    2018-11-07 v1
  • Checksum
    D90B5EE66FF45548
MTEQQPIAVLGGGSFGTAIANLLAENGHSVRLWMRDAEQAESIRTHRQNPRYLKGVTLLPGVCPVTDLGQTLAECQLIFVALPSSALRQALSPFADHLSGKMLVSTTKGIEAQGFMLMSQILEEIAPQARIGVISGPNLAREVAEHALTATVVASDDEALCRCVQQALHGRTFRVYASSDRFGVELGGALKNVYAIMAGMAAALGMGENTRSMLITRALAEMTRFAVRLGANPMTFLGLAGVGDLIVTCTSTKSRNFQVGHALGEGLSLDEAVSRLGEVAEGVNTIKVLKTKAEELQVYMPLVAGLHAILYEGRTLDQVIALLMRGEPKTDVDFISTDGF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNTV01000014
EMBL· GenBank· DDBJ
RBA54887.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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