A0A365PS58 · A0A365PS58_9GAMM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163650100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site194-201ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site494Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      DQ403_15305

Organism names

  • Taxonomic identifier
  • Strain
    • SST2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Stutzerimonas

Accessions

  • Primary accession
    A0A365PS58

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane98-120Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain186-325AAA+ ATPase
Region599-636Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    636
  • Mass (Da)
    69,311
  • Last updated
    2018-11-07 v1
  • Checksum
    52FE5B7C68C92868
MAKNLILWLIIAAVLVTVMNNFSSPTEPQTLNYSDFIEQVKEGQVERVTVDGFVITGKRSDGETFKTIRPAIQDNGLIGDLINNDVVIEGKQPEQQSIWTQLLVASFPILVIIAVFMFFMRQMQGGAGGKGGPMSFGKSKARLLSEDQVKTTFADVAGCDEAKEEVTELVEFLRDPGKFQRLGGRIPRGVLMVGSPGTGKTLLAKAVAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKHAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFEMNDGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDIRGREQILKVHMRKVPLGDTVEPALIARGTPGFSGADLANLVNEASLFAARAGKRVVEMKEFELAKDKIMMGAERKSMVMSEKERLNTAYHEAGHAIVGRVVPEHDPVYKVSIIPRGRALGVTMFLPEEDRYSLSKRALISQICSLFGGRIAEEMTLGFEGVTTGASNDIMRATQLARNMVTKWGLSEKLGPLMYAEEEGEVFLGRSAGSQHTNVSGDTAKLIDLEVRSIIDQCYGTAKQILADNRDKLDVMAETLMKYETIDADQIDDIMAGRTPREPRDWQDGSGPTGTPVQPEGGRPQTPIGGPAGEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNTV01000012
EMBL· GenBank· DDBJ
RBA55668.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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