A0A365PS40 · A0A365PS40_9GAMM

Function

function

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site18GTP (UniProtKB | ChEBI)
Binding site25[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site29[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site31S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site32[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site67GTP (UniProtKB | ChEBI)
Binding site71S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site98GTP (UniProtKB | ChEBI)
Binding site122S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site159GTP (UniProtKB | ChEBI)
Binding site193S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site257[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site260[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site262-264GTP (UniProtKB | ChEBI)
Binding site274[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclic pyranopterin monophosphate synthase activity
Molecular FunctionGTP 3',8'-cyclase activity
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological ProcessMo-molybdopterin cofactor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP 3',8-cyclase
  • EC number
  • Alternative names
    • Molybdenum cofactor biosynthesis protein A

Gene names

    • Name
      moaA
    • ORF names
      DQ403_16445

Organism names

  • Taxonomic identifier
  • Strain
    • SST2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Stutzerimonas

Accessions

  • Primary accession
    A0A365PS40

Proteomes

Interaction

Subunit

Monomer and homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-233Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    36,961
  • Last updated
    2018-11-07 v1
  • Checksum
    53829F7E263D06E2
MPDSKLVDPFGRRITYLRLSVTDRCDFRCTYCMSEDMVFAPRAQILTLEELYAVADAFISLGVKRIRVTGGEPLVRKGLPSLLSRLGAREELEDLSITTNGSQLTTLAPVLRDAGVKRLNISLDSLKRERFAELTRRDMLAQVVAGIDAARNAGFDRIKLNSVIQKGRNDDEVLDLVNFAVERGLDISFIEEMPLGNVSSHEREITFCSSEEVRERIEAGHQLVRSSHTTGGPSRYWQVAGSDTQVGFISPHSNNFCGSCNRVRVTAEGKLVLCLGHEGALDLKTLMRRHPGDSERLRQALVNALQLKPEKHEFRTDEQVQVVRFMSMTGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNTV01000013
EMBL· GenBank· DDBJ
RBA55345.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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