A0A365PQW3 · A0A365PQW3_9GAMM

Function

function

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site66substrate
Binding site69substrate
Binding site100-103NAD+ (UniProtKB | ChEBI)
Active site118Proton acceptor
Binding site126Zn2+ (UniProtKB | ChEBI)
Binding site129Zn2+ (UniProtKB | ChEBI)
Binding site154Zn2+ (UniProtKB | ChEBI)
Binding site157Zn2+ (UniProtKB | ChEBI)
Binding site194-196NAD+ (UniProtKB | ChEBI)
Binding site220-222NAD+ (UniProtKB | ChEBI)
Binding site238NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      DQ403_18005

Organism names

  • Taxonomic identifier
  • Strain
    • SST2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Stutzerimonas

Accessions

  • Primary accession
    A0A365PQW3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-253Deacetylase sirtuin-type

Domain

2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    27,209
  • Last updated
    2018-11-07 v1
  • Checksum
    FC86290EBCEF5F28
MIPASLVDALRSARHVVVFTGAGVSAESGIPTFRDSLTGLWERFDAASLATPEAFQADPPLVWGWYEWRRMKVLQAQPNPAHVAIAELARHVPRLTLVTQNVDDLHERAGSTDVIHLHGSLHQPRCFSCGERPDTPLGMPDEPEGGRRLEPPSCNACGAKLRPGVVWFGESLPTEALNTAFAAAENCDLLISVGTSGMVYPAAEVPGLAWRAGAVVVHVNPQPNTDQSEREFALAGLAGEQLPQLVDLAFGDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNTV01000017
EMBL· GenBank· DDBJ
RBA54225.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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