A0A365P9B7 · A0A365P9B7_9ACTN
- ProteinRibonuclease HII
- GenernhB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids234 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 45 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 46 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 139 | a divalent metal cation (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribonuclease H2 complex | |
Molecular Function | manganese ion binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | DNA replication, removal of RNA primer | |
Biological Process | mismatch repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease HII
- EC number
- Short namesRNase HII
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Dietziaceae > Dietzia
Accessions
- Primary accessionA0A365P9B7
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length234
- Mass (Da)24,840
- Last updated2018-11-07 v1
- Checksum473218F06B8F456F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QNTT01000026 EMBL· GenBank· DDBJ | RBA35277.1 EMBL· GenBank· DDBJ | Genomic DNA |