A0A365P9B7 · A0A365P9B7_9ACTN

  • Protein
    Ribonuclease HII
  • Gene
    rnhB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site45a divalent metal cation (UniProtKB | ChEBI)
Binding site46a divalent metal cation (UniProtKB | ChEBI)
Binding site139a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribonuclease H2 complex
Molecular Functionmanganese ion binding
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer
Biological Processmismatch repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease HII
  • EC number
  • Short names
    RNase HII

Gene names

    • Name
      rnhB
    • ORF names
      DQ226_10705

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SST1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Dietziaceae > Dietzia

Accessions

  • Primary accession
    A0A365P9B7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-230RNase H type-2

Sequence similarities

Belongs to the RNase HII family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    234
  • Mass (Da)
    24,840
  • Last updated
    2018-11-07 v1
  • Checksum
    473218F06B8F456F
MSRARPQRPRGVALPGRVRVTRRDGRLALEAALARRGLGPVAGVDEAGRGSCAGPLVVAACVLGDRLHPDLADLDDSKKLTAATRERLHDVILRRASAVSVVVIEPDRIDMRGIHRCNLEGMRRAVAALDPAPGFVLTDGFAVDGLGCQSTSVIGGDAVVASIAAASVLAKVTRDRIMVDLDLRYPGYGFVAHKGYSTVSHARAIEQLGPSGIHRMSYANVRRAAQAHSRSSTR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNTT01000026
EMBL· GenBank· DDBJ
RBA35277.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help