A0A355QDT5 · A0A355QDT5_UNCDE
- Proteinglycine dehydrogenase (aminomethyl-transferring)
- GenegcvP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids789 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H+ = N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | glycine cleavage complex | |
Cellular Component | membrane | |
Molecular Function | glycine binding | |
Molecular Function | glycine dehydrogenase (decarboxylating) activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameglycine dehydrogenase (aminomethyl-transferring)
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia
Accessions
- Primary accessionA0A355QDT5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 163-184 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 538 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-273 | Glycine cleavage system P-protein N-terminal | |||
Domain | 293-578 | Glycine cleavage system P-protein N-terminal | |||
Domain | 610-731 | Glycine dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the GcvP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length789
- Mass (Da)87,291
- Last updated2018-11-07 v1
- MD5 Checksum306AA57DBB7194919A5F82A00A4A1A66
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DNZT01000372 EMBL· GenBank· DDBJ | HBM54754.1 EMBL· GenBank· DDBJ | Genomic DNA |