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A0A355QDT5 · A0A355QDT5_UNCDE

Function

function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentglycine cleavage complex
Cellular Componentmembrane
Molecular Functionglycine binding
Molecular Functionglycine dehydrogenase (decarboxylating) activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine decarboxylation via glycine cleavage system

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycine dehydrogenase (aminomethyl-transferring)
  • EC number

Gene names

    • Name
      gcvP
    • ORF names
      DDZ97_16775

Organism names

Accessions

  • Primary accession
    A0A355QDT5

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane163-184Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue538N6-(pyridoxal phosphate)lysine

Interaction

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-273Glycine cleavage system P-protein N-terminal
Domain293-578Glycine cleavage system P-protein N-terminal
Domain610-731Glycine dehydrogenase C-terminal

Sequence similarities

Belongs to the GcvP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    789
  • Mass (Da)
    87,291
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    306AA57DBB7194919A5F82A00A4A1A66
KKKSKQFFVDRNLHRQTLDLLQTRAEPMNIQLVVGEPAEIPSGDYFGALLQCPNTFGPINDWSEWIEAMHQQGVLVAVATDLLSLTLLKPPGEMGADIVFGSAQRFGVPMGYGGPHAAFLATRDTLKRSLPGRLIGVSQDRQGQLALRMALQTREQHIRREKATSNICTAQVLLAVIASFYAIYHGPEGLKKIARRTHTLTALLRQGLNQGGFVSNDQFFDTLCIETKTQQPEILQRAQEAKMNLRVIDSTHLGVSLDETTTPEDVSKLLKVFGVEVDLDSLLSQANSSDAGIPESLRRVSDFLSHPVFHRYHSETDLMRYLRNLEEKDLALNRAMIPLGSCTMKLNASAEMIPVTWESVGSLHPFVPLEQAQGMQKMIQQLEDWLMQLTGFDAISMQPNSGAQGEYAGLLTIRNYHISQGEVHRHICLIPSSAHGTNPASAQMAGMKVVVVNCDSQGNVDVNDLRQKAEAHASELAALMVTYPSTHGVFEEEICNICEIIQGFGGQVYMDGANLNALVGIAQPGQFGPDVMHFNLHKTFCIPHGGGGPGMGPIGVRSHLAPYLPNHSIIKVAENRTGGAVSAAPWGSPSILPISWMYIRMMGGPNLRTASQVAILNANYMAERLSDAYPILYRGRNGRLAHECILDIRPLKNNSGISEEDIAKRLMDYGFHAPTMSWPVAGTLMIEPTESESREELDRFCEAMLKIREEVRQVEEGTWPLEDNPLVNAPHTQLDLTAEVWTHPYTREIAAYPLPGMQTQKFWPTVNRIDNAYGDRNLVCSCPTVESYR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DNZT01000372
EMBL· GenBank· DDBJ
HBM54754.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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