A0A355Q6V7 · A0A355Q6V7_UNCDE
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 178-180 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 205 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 246 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia
Accessions
- Primary accessionA0A355Q6V7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-133 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | |||
Domain | 136-301 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | |||
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)33,706
- Last updated2018-11-07 v1
- MD5 Checksum1D96D6D0C83832A89B40C370F42AE427
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DNZT01000217 EMBL· GenBank· DDBJ | HBM53351.1 EMBL· GenBank· DDBJ | Genomic DNA |