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A0A355Q5M4 · A0A355Q5M4_UNCDE

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site25-27shikimate (UniProtKB | ChEBI)
Binding site72shikimate (UniProtKB | ChEBI)
Active site76Proton acceptor
Binding site88NADP+ (UniProtKB | ChEBI)
Binding site97shikimate (UniProtKB | ChEBI)
Binding site112shikimate (UniProtKB | ChEBI)
Binding site136-140NADP+ (UniProtKB | ChEBI)
Binding site227NADP+ (UniProtKB | ChEBI)
Binding site229shikimate (UniProtKB | ChEBI)
Binding site250NADP+ (UniProtKB | ChEBI)
Binding site257shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      DDZ97_07465

Organism names

Accessions

  • Primary accession
    A0A355Q5M4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-99Shikimate dehydrogenase substrate binding N-terminal
Domain126-192Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain252-279SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    30,558
  • Last updated
    2018-11-07 v1
  • MD5 Checksum
    CC0D934FA19045D7904D9CA5C264E757
MRVSESMIHGTTQIYGVIGDPISHSLSPSLQNPAFAALGIDAVYVTFRVVPSSLGDALRGLLALNVQGINVTVPHKSDVFQYLDEVTDTARKIGAVNTLRNDSGHWIGENTDATGFIRSLEPLGLSLSGSSVGMLGAGGAARGVAVGLLNAGVSRLFICNRNHERAIVLVELLQASFGQQSVRAVSLEQIEKEELHLLVNTTTVGSDGYSIPANLSRFDKLEAVADIIYRPSRTPLLLEAEKLGLPNLNGGGMLLYQGTAAFSFWTGRPAPEIIMRKALDEHLSKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DNZT01000175
EMBL· GenBank· DDBJ
HBM52916.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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