A0A355Q5M4 · A0A355Q5M4_UNCDE
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids286 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 25-27 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 72 | shikimate (UniProtKB | ChEBI) | |||
Active site | 76 | Proton acceptor | |||
Binding site | 88 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 97 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 112 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 136-140 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 227 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 229 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 250 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 257 | shikimate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia
Accessions
- Primary accessionA0A355Q5M4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 17-99 | Shikimate dehydrogenase substrate binding N-terminal | |||
Domain | 126-192 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | |||
Domain | 252-279 | SDH C-terminal | |||
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length286
- Mass (Da)30,558
- Last updated2018-11-07 v1
- MD5 ChecksumCC0D934FA19045D7904D9CA5C264E757
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DNZT01000175 EMBL· GenBank· DDBJ | HBM52916.1 EMBL· GenBank· DDBJ | Genomic DNA |