A0A354AQD5 · A0A354AQD5_9GAMM

  • Protein
    Acetyl-coenzyme A synthetase
  • Gene
    acs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191-194CoA (UniProtKB | ChEBI)
Binding site311CoA (UniProtKB | ChEBI)
Binding site335CoA (UniProtKB | ChEBI)
Binding site387-389ATP (UniProtKB | ChEBI)
Binding site411-416ATP (UniProtKB | ChEBI)
Binding site500ATP (UniProtKB | ChEBI)
Binding site515ATP (UniProtKB | ChEBI)
Binding site523CoA (UniProtKB | ChEBI)
Binding site526ATP (UniProtKB | ChEBI)
Binding site537Mg2+ (UniProtKB | ChEBI)
Binding site539Mg2+ (UniProtKB | ChEBI)
Binding site542Mg2+ (UniProtKB | ChEBI)
Binding site584CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate
Biological Processchemotaxis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acs
    • ORF names
      EpCFBP13511_18790

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CFBP13511
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia

Accessions

  • Primary accession
    A0A354AQD5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue609N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-81Acetyl-coenzyme A synthetase N-terminal
Domain83-466AMP-dependent synthetase/ligase
Domain531-609AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    651
  • Mass (Da)
    71,568
  • Last updated
    2018-11-07 v1
  • Checksum
    FF701C068B6DAD31
MSQSHTYPVPANIAENTLIAPQQYSSMYQQSVQDPDAFWGEQGKILDWIKPFTVVKNTSFAPGNVSIRWFEDGTLNLAANCLDRHLATRGDHPAIIWEGDDSSESKTITYRELHRDVCRFANTLKELGISKGDVVAIYMPMVPEAAVAMLACARIGAVHTVIFGGFSPEAVAGRIIDCNARLVITADEGIRAGRAIPLKKNVDDALNNPNVTSVGNVVVFRRTGKDVGWKNDRDLWWHELVNKASAHHQPEEVGAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPDDVYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPKPSRMAEVVDKHKVTILYTAPTAVRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWFHKKIGNGRCPIVDTWWQTETGGFMITPLPGATALKPGSATNPFFGVQPALVDNEGNALEGATEGNLVIVDSWPGQARTLYGDHERFEQTYFSTFKNMYFSGDGARRDEEGYYWITGRVDDVLNVSGHRLGTAEIESALVSHPLIAEAAVVGIPHGLKGQAIYAYITLNHGEEPSPELYTEVRNWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQSIKMP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGAC01000020
EMBL· GenBank· DDBJ
TKJ86169.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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