A0A354AAG6 · A0A354AAG6_9GAMM

  • Protein
    DNA topoisomerase 4 subunit B
  • Gene
    parE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

163150100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site6ATP (UniProtKB | ChEBI)
Binding site43ATP (UniProtKB | ChEBI)
Binding site70ATP (UniProtKB | ChEBI)
Binding site111-117ATP (UniProtKB | ChEBI)
Binding site335ATP (UniProtKB | ChEBI)
Site447Interaction with DNA
Site498Interaction with DNA
Site616Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      EpCFBP13511_14090

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CFBP13511
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia

Accessions

  • Primary accession
    A0A354AAG6

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain413-526Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    631
  • Mass (Da)
    69,931
  • Last updated
    2018-11-07 v1
  • Checksum
    844EC5520320E61A
MTQSSYNADSIEVLSGLEPVRRRPGMYTDTVRPNHLGQEVIDNSVDEALAGHAKRVEVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELIFCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRNGEVYEMAFENGDKVQDLTVTGTVGKRNTGTRVQFWPDESFFDSPRFSVSRLSHLLKAKAVLCPGVEIVFKDKLNNTEQTWCYADGLTDYLMEAVNGLPTLPEKAFVGAFAGDVEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEMLAELAISSAQRRLRAAKKVVRKKLTSGPALPGKLADCSAQDLARTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQLRYGKICILADADSDGLHIATLLCALFVRHFSTLVKNGHVYVAMPPLYRIDLGKEVYYALDEEEKAGILEQLKRKKGKPGVQRFKGLGEMNPLQLRETTLDPNTRRLVQLTISDEDLPHTMAVMDMLLAKKRSEDRRNWLQEKGDMAEIEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGAC01000013
EMBL· GenBank· DDBJ
TKJ88982.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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