A0A352X6U0 · A0A352X6U0_9CYAN

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

170450100150200250300350400450500550600650700
Type
IDPosition(s)Description
Binding site272-279ATP (UniProtKB | ChEBI)
Binding site497Zn2+ (UniProtKB | ChEBI); catalytic
Active site498
Binding site501Zn2+ (UniProtKB | ChEBI); catalytic
Binding site574Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane-derived thylakoid membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      DDW51_09025

Organism names

Accessions

  • Primary accession
    A0A352X6U0

Proteomes

Subcellular Location

Cellular thylakoid membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane179-200Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region88-149Disordered
Compositional bias96-145Polar residues
Domain264-406AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    704
  • Mass (Da)
    76,678
  • Last updated
    2018-11-07 v1
  • Checksum
    987FBDC2E86CE9BB
MSIKKKPKSPRIPQIGYILLILAGVSFLGYLFIPRSPKFPRVPYSSFLDQVEEGKVLRVKMGDNQILYQLKNEDPLKAAQELLRATPDPIKGTEKLLQPTPNSTQGTTSTEKLLQPTPSALQPTPSPLQTNRDQNVLTQPQEPQGPIYETIPVNDPDLAKKLREKKVEFFALPPAQESWFSVLLSWVIPPIILVAAFQFFMKRTDVDGQSLSFSKSKAKVYVEGESAKITFADVAGADEAKVELVEIVEFLKDPQRFTEIGARIPKGVLLVGPPGTGKTLLAKAVAGEAGVSFFSISASEFVELFVGTGAARVRDLFVQAKTKAPCIIFIDELDAIGKSRSSGNSPSGGNDEREQTLNQLLTEMDGFAAGNATVIVLAATNRPESLDRALLRPGRFDRQVLVDRPDLVGREAILNVYARKVKLADDIDLHKIAARTPGFAGADLANLVNEAALLAARARRETVSAADFAEAIERVIAGSEKKSRVLNEKEKKIVAYHEVGHALVGALMPGTGKVAKISIVPRGMSALGYTLQLPTEDRFLMNEAELRGDIATLLGGRVAEEIIFGDVTTGASNDLQRATDVAERMVTTYGMGKVMGPLAYDLAPQNNFLGNGVNIRRNVSEETAKAIDKEVKEIVETAHQMASDILNHNRDLLESIAQEILKTEVIEGEELQNWLSQVKPVDPVTDGVLVNNYNGRLVEGNFLG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias96-145Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DNOY01000199
EMBL· GenBank· DDBJ
HBE17739.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp