A0A351IU65 · A0A351IU65_9ACTN
- ProteinGTP 3',8-cyclase
- GenemoaA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids327 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Catalytic activity
- GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H+
Cofactor
Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
Pathway
Cofactor biosynthesis; molybdopterin biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17 | GTP (UniProtKB | ChEBI) | |||
Binding site | 24 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 28 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 30 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 31 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet | |||
Binding site | 68 | GTP (UniProtKB | ChEBI) | |||
Binding site | 72 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 97 | GTP (UniProtKB | ChEBI) | |||
Binding site | 121 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 158 | GTP (UniProtKB | ChEBI) | |||
Binding site | 192 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 254 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate | |||
Binding site | 257 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate | |||
Binding site | 259-261 | GTP (UniProtKB | ChEBI) | |||
Binding site | 271 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | cyclic pyranopterin monophosphate synthase activity | |
Molecular Function | GTP 3',8'-cyclase activity | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Molecular Function | S-adenosyl-L-methionine binding | |
Biological Process | Mo-molybdopterin cofactor biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP 3',8-cyclase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillati > Actinomycetota > Acidimicrobiia > Acidimicrobiales > Acidimicrobiaceae
Accessions
- Primary accessionA0A351IU65
Proteomes
Interaction
Subunit
Monomer and homodimer.
Structure
Sequence
- Sequence statusComplete
- Length327
- Mass (Da)36,037
- Last updated2018-11-07 v1
- MD5 Checksum16E347B1F6456D50C9CE2F596001FD03
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DNIH01000098 EMBL· GenBank· DDBJ | HAZ17585.1 EMBL· GenBank· DDBJ | Genomic DNA |