A0A348TQT8 · A0A348TQT8_9BACT

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site148-151substrate
Binding site171substrate
Binding site176-177substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      DCR46_05770

Organism names

Accessions

  • Primary accession
    A0A348TQT8

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    21,564
  • Last updated
    2018-11-07 v1
  • Checksum
    6ED48150140885BC
MHLCFATQNRHKLQEIQALLPAGVSLVTPAELGCMEELPETQHTLEGNSAQKADYLFENYNIDCFADDTGLEIEALHGAPGVFSAMYAGKEKNAEANMRLVLENLHNCKNRKARFRTVITLILNGRKEVFEGILEGEILGKPKGSHGFGYDPIFIPKGFTQTLAEMTMQEKNQISHRSLAFKQLREFLAPIVS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DMUD01000200
EMBL· GenBank· DDBJ
HAR20150.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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