A0A346FJK3 · A0A346FJK3_BPT6

Function

function

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.

Catalytic activity

  • Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
    EC:3.2.1.17 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

116420406080100120140160
TypeIDPosition(s)Description
Active site11Proton donor/acceptor
Active site20Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Molecular Functionlysozyme activity
Biological Processcell wall macromolecule catabolic process
Biological Processdefense response to bacterium
Biological Processpeptidoglycan catabolic process
Biological Processviral release from host cell by cytolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endolysin
  • EC number
  • Alternative names
    • Lysis protein
    • Lysozyme
    • Muramidase

Gene names

    • Name
      e
    • ORF names
      EcT6_00117

Organism names

Accessions

  • Primary accession
    A0A346FJK3

Proteomes

Subcellular Location

Host cytoplasm
Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    164
  • Mass (Da)
    18,606
  • Last updated
    2018-11-07 v1
  • Checksum
    605DE30F679414A0
MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLSVAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVIATFRTGTWDAYKNL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH550421
EMBL· GenBank· DDBJ
AXN58158.1
EMBL· GenBank· DDBJ
Genomic DNA
AP018814
EMBL· GenBank· DDBJ
BBF63542.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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