A0A346FJ69 · A0A346FJ69_9CAUD
- ProteinAntitermination protein Q
- Gene58
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids207 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes.
Features
Showing features for site, binding site, dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 101 | Interaction with host rpoB | |||
Binding site | 118 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 121 | Zn2+ (UniProtKB | ChEBI) | |||
Site | 134 | Interaction with host RNA polymerase sigma factor RPOD | |||
Binding site | 144 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 147 | Zn2+ (UniProtKB | ChEBI) | |||
Site | 160 | Interaction with host rpoB | |||
Site | 165 | Interaction with host rpoB | |||
DNA binding | 171-192 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | DNA-templated transcription termination | |
Biological Process | transcription antitermination |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAntitermination protein Q
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Lambdavirus > Lambdavirus lvO276
Accessions
- Primary accessionA0A346FJ69
Proteomes
Interaction
Subunit
Interacts with host RPOB (via flap domain); this interaction renders host RNAP resistant to transcription pausing and allows it to read through termination signals. Interacts with host RNA polymerase sigma factor RPOD (via domain-4). Interacts with host NUSA (via N-terminus and AR2 domain); this interaction releases the autoinhibition of NUSA.
Sequence
- Sequence statusComplete
- Length207
- Mass (Da)22,473
- Last updated2018-11-07 v1
- Checksum12D4D3AF93DBACDB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MH547045 EMBL· GenBank· DDBJ | AXN58024.1 EMBL· GenBank· DDBJ | Genomic DNA |