A0A346FJ69 · A0A346FJ69_9CAUD

Function

function

Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes. Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP. To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation. Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes.

Features

Showing features for site, binding site, dna binding.

120720406080100120140160180200
Type
IDPosition(s)Description
Site101Interaction with host rpoB
Binding site118Zn2+ (UniProtKB | ChEBI)
Binding site121Zn2+ (UniProtKB | ChEBI)
Site134Interaction with host RNA polymerase sigma factor RPOD
Binding site144Zn2+ (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)
Site160Interaction with host rpoB
Site165Interaction with host rpoB
DNA binding171-192

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription termination
Biological Processtranscription antitermination

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Antitermination protein Q

Gene names

    • Name
      58
    • Synonyms
      Q
    • ORF names
      O276_58

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Lambdavirus > Lambdavirus lvO276

Accessions

  • Primary accession
    A0A346FJ69

Proteomes

Interaction

Subunit

Interacts with host RPOB (via flap domain); this interaction renders host RNAP resistant to transcription pausing and allows it to read through termination signals. Interacts with host RNA polymerase sigma factor RPOD (via domain-4). Interacts with host NUSA (via N-terminus and AR2 domain); this interaction releases the autoinhibition of NUSA.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, zinc finger.

Type
IDPosition(s)Description
Region1-28Disordered
Zinc finger118-147

Sequence similarities

Belongs to the phage antitermination Q type 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    22,473
  • Last updated
    2018-11-07 v1
  • Checksum
    12D4D3AF93DBACDB
MRLESVAKFHSPKSPMMSDSPRATASDSLSGTDVMAAMGMAQSQAGFGMAAFCGKHELSQNDKQKAINYLMQFAHKVSGKYRGVAKLEGNTKAKVLQVLATFAYADYCRSAATPGARCRDCHGTGRAVDIAKTELWGRVVEKECGRCKGVGYSRMPASAAYRAVTMLIPNLTQPTWSRTVKPLYDALVVQCHKEESIADNILNAVTR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH547045
EMBL· GenBank· DDBJ
AXN58024.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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