A0A346D7I7 · A0A346D7I7_9GAMM
- ProteinMalate dehydrogenase
- Genemdh
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids313 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity
- (S)-malate + NAD+ = H+ + NADH + oxaloacetate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-13 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GAAGGIG | ||||||
Binding site | 34 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 81 | substrate | ||||
Sequence: R | ||||||
Binding site | 87 | substrate | ||||
Sequence: R | ||||||
Binding site | 94 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 117-119 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: ITN | ||||||
Binding site | 119 | substrate | ||||
Sequence: N | ||||||
Binding site | 153 | substrate | ||||
Sequence: R | ||||||
Active site | 177 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 227 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: M |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | L-malate dehydrogenase activity | |
Biological Process | malate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMalate dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Pectobacteriaceae > Dickeya
Accessions
- Primary accessionA0A346D7I7
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-145 | Lactate/malate dehydrogenase N-terminal | ||||
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTDVKIKGFSGEDATPALEGADIVLMSAGVARKPGMDRSDLFNVNAGIVRNLVSQIARTCPNACIGIITNPVNTTVAIAAEVLEQAGVYNKDKLFG | ||||||
Domain | 147-310 | Lactate/malate dehydrogenase C-terminal | ||||
Sequence: TTLDIIRSSTFVAELKDKQPQAIDVPVIGGHSGVTILPLLSRIPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGESGVVECAYVEGDGKHARFFAQPLLLGKNGVAERKDIGTLSAFEQQALVSMLDTLKQDIALGEEFV |
Sequence similarities
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length313
- Mass (Da)32,544
- Last updated2018-11-07 v1
- Checksum005E8F3E39B46E70
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MH118538 EMBL· GenBank· DDBJ | AXM43026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAHEPU010000002 EMBL· GenBank· DDBJ | MBT1458245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VZQG01000015 EMBL· GenBank· DDBJ | MZG33415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP069601 EMBL· GenBank· DDBJ | QVH63964.1 EMBL· GenBank· DDBJ | Genomic DNA |