A0A346AFT9 · A0A346AFT9_9BACT

  • Protein
    RNA 3'-terminal phosphate cyclase
  • Gene
    rtcA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

Features

Showing features for binding site, active site.

135050100150200250300350
Type
IDPosition(s)Description
Binding site100ATP (UniProtKB | ChEBI)
Binding site286-290ATP (UniProtKB | ChEBI)
Active site311Tele-AMP-histidine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionRNA-3'-phosphate cyclase activity
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA 3'-terminal phosphate cyclase
  • EC number
  • Short names
    RNA cyclase
    ; RNA-3'-phosphate cyclase

Gene names

    • Name
      rtcA

Organism names

Accessions

  • Primary accession
    A0A346AFT9

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-329RNA 3'-terminal phosphate cyclase
Domain182-277RNA 3'-terminal phosphate cyclase insert

Sequence similarities

Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    37,622
  • Last updated
    2018-11-07 v1
  • Checksum
    C93F7C840404553F
MLTIDGSQGEGGGQIIRTSLALALITGRPFRIYNVRARREKPGLQRQHLTAVLAAAKIGNAQVEGASLGSSAFTFTPGQVTPGDYSFPIGTAGSTSLVLQTILPPLMTAASPSTLAFEGGTHNVHAPPYEFLVKTFLPLINRMGPRVSVELQRYGFYPPGGGRFSVLIEPAGSALTPLRLLTRGEIRARRARALVVKLPPTVGERELTVVREQLGWNEDAGDELRVETSTNALSPGNVLTLEIESEHLTEVFTGIGERGVRAETVAERAAQEAHAYLETGAPVGEHLADQLLIPFALARGGAFSTGQPSLHTTTNIEVVQMFLDVEIKVREMEGEAWRIEVSGQEERVKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH480551
EMBL· GenBank· DDBJ
AXL06101.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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