A0A343RQX0 · A0A343RQX0_MAMPR
- ProteinNADH-ubiquinone oxidoreductase chain 3
- GeneND3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 3
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Afrotheria > Proboscidea > Elephantidae > Mammuthus
Accessions
- Primary accessionA0A343RQX0
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 55-79 | Helical | ||||
Sequence: FFLVAITFLLFDLEIALLLPLPWAI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MNLMATXXXXXMLTSLMVLIAFWLPQTYT | ||||||
Chain | PRO_5016634040 | 30-87 | NADH-ubiquinone oxidoreductase chain 3 | |||
Sequence: YSEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQANNTNLT |
Structure
Sequence
- Sequence statusFragment
- Length87
- Mass (Da)9,887
- Last updated2018-11-07 v1
- Checksum88917F096804B51A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 87 | |||||
Sequence: T |