A0A343KKE7 · A0A343KKE7_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

135850100150200250300350
TypeIDPosition(s)Description
Binding site72Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site86Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site171Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site185Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site190a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A343KKE7

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-45Helical
Transmembrane66-87Helical
Transmembrane102-122Helical
Transmembrane129-147Helical
Transmembrane167-189Helical
Transmembrane218-235Helical
Transmembrane277-297Helical
Transmembrane309-328Helical
Transmembrane334-355Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-198Cytochrome b/b6 N-terminal region profile
Domain199-358Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    358
  • Mass (Da)
    40,008
  • Last updated
    2018-11-07 v1
  • Checksum
    37760F92B7E159B4
KLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLXSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTIXXXXXTI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue358

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF588795
EMBL· GenBank· DDBJ
ATI23747.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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