A0A341CMX6 · A0A341CMX6_NEOAA

Function

function

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.

Catalytic activity

  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.
    EC:3.1.4.38 (UniProtKB | ENZYME | Rhea)
  • sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionglycerophosphocholine cholinephosphodiesterase activity
Molecular Functionglycerophosphodiester phosphodiesterase activity
Biological Processcholine metabolic process
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycerophosphocholine cholinephosphodiesterase
  • EC number
  • Alternative names
    • Choline-specific glycerophosphodiester phosphodiesterase
    • Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Gene names

    • Name
      ENPP6

Organism names

Accessions

  • Primary accession
    A0A341CMX6

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_501640213023-374glycerophosphocholine cholinephosphodiesterase

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Homotetramer.

Family & Domains

Sequence similarities

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    374
  • Mass (Da)
    43,398
  • Last updated
    2018-10-10 v1
  • Checksum
    65DA56A09B368F33
MAEKLGALLLALVLSLAQPAPARRKLLVFLLDGFRSDYISDEVLESLPGFREIVSRGVKADYLTPDFPSLSYPNYYSLMTGRHCEVHQMIGNYMWDPATNKSFDIGVNRDSLMPLWWNGSEPLWITLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDFFKSGQADLVAIYYERIDVEGHHYGPSSPQRKEALRAVDTVLKYMTTWIQERELQDDLNVIIFSDHGMTDIFWMDKVIELDKYISLHDLQQVKDRGPVVSLWPVPGKHSEIYNKLRTVEHMTVYKKEAIPSRFYYKKGKFVSPLTLVADEGWFITENRETLPFWMNSTDKRQGWQRGWHGYDNELRDMRGIFLAFGPAI

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A341CLS6A0A341CLS6_NEOAAENPP6440
A0A341CM56A0A341CM56_NEOAAENPP6384
A0A341CM89A0A341CM89_NEOAAENPP6378
A0A341CMX1A0A341CMX1_NEOAAENPP6452
A0A341CPF6A0A341CPF6_NEOAAENPP6392

Keywords

Sequence databases

Similar Proteins

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