A0A341CMX6 · A0A341CMX6_NEOAA
- Proteinglycerophosphocholine cholinephosphodiesterase
- GeneENPP6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
Catalytic activity
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+This reaction proceeds in the forward direction.
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | glycerophosphocholine cholinephosphodiesterase activity | |
Molecular Function | glycerophosphodiester phosphodiesterase activity | |
Biological Process | choline metabolic process | |
Biological Process | lipid catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameglycerophosphocholine cholinephosphodiesterase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Phocoenidae > Neophocaena
Accessions
- Primary accessionA0A341CMX6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5016402130 | 23-374 | glycerophosphocholine cholinephosphodiesterase | ||
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked. Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)43,398
- Last updated2018-10-10 v1
- Checksum65DA56A09B368F33
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A341CLS6 | A0A341CLS6_NEOAA | ENPP6 | 440 | ||
A0A341CM56 | A0A341CM56_NEOAA | ENPP6 | 384 | ||
A0A341CM89 | A0A341CM89_NEOAA | ENPP6 | 378 | ||
A0A341CMX1 | A0A341CMX1_NEOAA | ENPP6 | 452 | ||
A0A341CPF6 | A0A341CPF6_NEOAA | ENPP6 | 392 |
Keywords
- Technical term