A0A341CM56 · A0A341CM56_NEOAA

Function

function

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.

Catalytic activity

  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.
    EC:3.1.4.38 (UniProtKB | ENZYME | Rhea)
  • sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+
    This reaction proceeds in the forward direction.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionglycerophosphocholine cholinephosphodiesterase activity
Molecular Functionglycerophosphodiester phosphodiesterase activity
Biological Processcholine metabolic process
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycerophosphocholine cholinephosphodiesterase
  • EC number
  • Alternative names
    • Choline-specific glycerophosphodiester phosphodiesterase
    • Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Gene names

    • Name
      ENPP6

Organism names

Accessions

  • Primary accession
    A0A341CM56

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_501638017523-384glycerophosphocholine cholinephosphodiesterase

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Homotetramer.

Family & Domains

Sequence similarities

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    44,633
  • Last updated
    2018-10-10 v1
  • MD5 Checksum
    EF2D4E7C1153D1594D98B7FF88B7BC02
MAEKLGALLLALVLSLAQPAPARRKLLVFLLDGFRSDYISDEVLESLPGFREIVSRGVKADYLTPDFPSLSYPNYYSLMTGRHCEVHQMIGNYMWDPATNKSFDIGVNRDSLMPLWWNGSEPLWITLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDFFKSGQADLVAIYYERIDVEGHHYGPSSPQRKEALRAVDTVLKYMTTWIQERELQDDLNVIIFSDHGMTDIFWMDKVIELDKYISLHDLQQVKDRGPVVSLWPVPGKHSEIYNKLRTVEHMTVYKKEAIPSRFYYKKGKFVSPLTLVADEGWFITENRETLPFWMNSTDKRQGWQRGWHGYDNELRDMRGIFLAFGPGMLFSQGKFYFL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A341CLS6A0A341CLS6_NEOAAENPP6440
A0A341CM89A0A341CM89_NEOAAENPP6378
A0A341CMX1A0A341CMX1_NEOAAENPP6452
A0A341CMX6A0A341CMX6_NEOAAENPP6374
A0A341CPF6A0A341CPF6_NEOAAENPP6392

Keywords

Sequence databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help