A0A340XCM7 · A0A340XCM7_LIPVE
- ProteinRho-associated protein kinase
- GeneROCK2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1389 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | Rho-dependent protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actomyosin structure organization | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | embryonic morphogenesis | |
Biological Process | mitotic cytokinesis | |
Biological Process | peptidyl-threonine phosphorylation | |
Biological Process | positive regulation of centrosome duplication | |
Biological Process | regulation of actin cytoskeleton organization | |
Biological Process | regulation of cell junction assembly | |
Biological Process | Rho protein signal transduction | |
Biological Process | rhythmic process | |
Biological Process | smooth muscle contraction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Lipotidae > Lipotes
Accessions
- Primary accessionA0A340XCM7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 83-345 | Protein kinase | ||||
Sequence: YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFF | ||||||
Domain | 348-416 | AGC-kinase C-terminal | ||||
Sequence: DQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDS | ||||||
Domain | 488-564 | REM-1 | ||||
Sequence: ALRQLEREKALLQHKNAEYQRKADQEADKKRNLENDVNSLKDQLEDLKKRNQNSQMSTEKVNQLQRQLDETNALLRT | ||||||
Region | 503-523 | Disordered | ||||
Sequence: NAEYQRKADQEADKKRNLEND | ||||||
Coiled coil | 646-1000 | |||||
Sequence: LKNGKILLAKVEIEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKWKDAQEQLSRLKDE | ||||||
Domain | 970-1038 | RhoBD | ||||
Sequence: TSDVANLANEKEELNNKWKDAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEP | ||||||
Coiled coil | 1047-1092 | |||||
Sequence: VRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQI | ||||||
Domain | 1141-1340 | PH | ||||
Sequence: ESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIP | ||||||
Domain | 1251-1306 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPC | ||||||
Region | 1341-1389 | Disordered | ||||
Sequence: KKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPSSGPALRIILH | ||||||
Compositional bias | 1354-1377 | Polar residues | ||||
Sequence: PRTSMKIQQNQSIRRPSRQLAPNK |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,389
- Mass (Da)160,929
- Last updated2018-10-10 v1
- ChecksumD4F32030A1638894
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A340X5X9 | A0A340X5X9_LIPVE | ROCK2 | 1379 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1354-1377 | Polar residues | ||||
Sequence: PRTSMKIQQNQSIRRPSRQLAPNK |
Keywords
- Technical term