A0A340XCM7 · A0A340XCM7_LIPVE

Function

function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by RHOA binding. Inhibited by Y-27632.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site112ATP (UniProtKB | ChEBI)
Active site205Proton acceptor

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionsmall GTPase binding
Biological Processactomyosin structure organization
Biological Processcortical actin cytoskeleton organization
Biological Processembryonic morphogenesis
Biological Processmitotic cytokinesis
Biological Processpeptidyl-threonine phosphorylation
Biological Processpositive regulation of centrosome duplication
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of cell junction assembly
Biological ProcessRho protein signal transduction
Biological Processrhythmic process
Biological Processsmooth muscle contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-associated protein kinase
  • EC number

Gene names

    • Name
      ROCK2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Lipotidae > Lipotes

Accessions

  • Primary accession
    A0A340XCM7

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Nucleus

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain83-345Protein kinase
Domain348-416AGC-kinase C-terminal
Domain488-564REM-1
Region503-523Disordered
Coiled coil646-1000
Domain970-1038RhoBD
Coiled coil1047-1092
Domain1141-1340PH
Domain1251-1306Phorbol-ester/DAG-type
Region1341-1389Disordered
Compositional bias1354-1377Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,389
  • Mass (Da)
    160,929
  • Last updated
    2018-10-10 v1
  • Checksum
    D4F32030A1638894
MPGAPEAVSGDGAGVSRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCKENDSIQSRKNEESQEIQKKLYTLEEHLSSEIQAKEELEQKCRSVNTRLEKVAKELEEEITLRKNVESALRQLEREKALLQHKNAEYQRKADQEADKKRNLENDVNSLKDQLEDLKKRNQNSQMSTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDLKNGKILLAKVEIEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKWKDAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPSSGPALRIILH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A340X5X9A0A340X5X9_LIPVEROCK21379

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1354-1377Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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