A0A340X7S9 · A0A340X7S9_LIPVE

Function

function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
    EC:3.4.21.7 (UniProtKB | ENZYME | Rhea)

Activity regulation

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site158L-lysine (UniProtKB | ChEBI)
Binding site172L-lysine (UniProtKB | ChEBI)
Binding site432L-lysine (UniProtKB | ChEBI)
Binding site445L-lysine (UniProtKB | ChEBI)
Active site620Charge relay system
Active site663Charge relay system
Active site758Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Functionserine-type endopeptidase activity
Molecular Functionsignaling receptor binding
Biological Processblood coagulation
Biological Processfibrinolysis
Biological Processproteolysis
Biological Processtissue remodeling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Plasminogen
  • EC number

Gene names

    • Name
      LOC103073034

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Lipotidae > Lipotes

Accessions

  • Primary accession
    A0A340X7S9

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_501646821620-808Plasminogen
Disulfide bond185↔262
Disulfide bond206↔245
Disulfide bond234↔257
Disulfide bond275↔352
Disulfide bond296↔335
Disulfide bond324↔347
Disulfide bond377↔454
Disulfide bond398↔437
Disulfide bond426↔449

Keywords

Interaction

Subunit

Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-98Apple
Domain102-181Kringle
Domain184-262Kringle
Domain274-352Kringle
Domain376-454Kringle
Domain480-560Kringle
Domain581-806Peptidase S1

Sequence similarities

Belongs to the peptidase S1 family. Plasminogen subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    808
  • Mass (Da)
    90,134
  • Last updated
    2018-10-10 v1
  • Checksum
    257E8B3362C8C3B1
MEHMEVVLLLLLFLKSGLGDPLDEYVNTQGASLFSLTRKQLVTGSIDECATKCEEESDFICRAFQYHSKEQQCVIMAENSKFSPVLRMRDVILFEKRMYLSECKTGTGKNYRGTVAKTKSGVACQKWSDNSPHTPNFSPEKYPSAGLEDNYCRNPDNDKKGPWCYTTDPSTRFDYCDIPQCEDECMHCSGENYEGKISKTVSGLDCQAWDSQSPHAHGYIPAKFPNKNLKMNYCRNPDGEPRPWCFTTDPSKRWEFCDIPRCTTPPPSSGPTYQCLKGRGESYRGTVAVTVSGHTCQRWREQTPHKHNRTPENFPCKNLEENYCRNPDGETGPWCYTTNSEVRWEYCTIPSCESSPLSVEHLDAPVPPEQTPVAQDCYQGNGQSYRGTSSTTITGRKCQSWSSMLPHRHQKTPENYPNAGLTMNYCRNPDADKSPWCYTTDPSVRWEFCNLKKCSETQEQVTESSAAAHVPSIVDPSEADCMFGTGKGYRGKKATTVAGVPCQAWAAQEPHKHNIFTPETNPRAGLEKNYCRNPDGDVNGPWCYTTNPRKLFDYCDVPYCASSSFDCGKPQIEPKKCPGRVVGGCVAAPHSWPWQVSLRKRSHFCGGTLISPEWVLTAAHCLDSFSGPASYKVILGAHKETAVEESVQEIQVTKLFPEPTRADIALLKLSSPAIITNKVIPACLPSPNYVVADRTVCYITGWGETQGTYGAGLLKEARLPVIENKVCNRYEYLNGRVKPTELCAGHLAGGADSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSKFVTWIEETMRKN

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A340XEK1A0A340XEK1_LIPVELOC103073034814
A0A340X8B6A0A340X8B6_LIPVELOC103073034807
A0A340X8C1A0A340X8C1_LIPVELOC103073034719
A0A340XF42A0A340XF42_LIPVELOC103073034812
A0A340XC28A0A340XC28_LIPVELOC103073034812
A0A340XC32A0A340XC32_LIPVELOC103073034807

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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