A0A337SQQ4 · A0A337SQQ4_FELCA

Function

function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacetylcholine-gated channel complex
Cellular Componentapical plasma membrane
Cellular Componentaxolemma
Cellular Componentcholinergic synapse
Cellular Componentexternal side of plasma membrane
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic specialization membrane
Cellular Componentpresynaptic membrane
Cellular Componentsynapse
Molecular Functionacetylcholine-gated monoatomic cation-selective channel activity
Molecular Functiontransmembrane signaling receptor activity
Biological Processassociative learning
Biological ProcessB cell activation
Biological Processbehavioral response to ethanol
Biological Processbehavioral response to nicotine
Biological Processdendrite arborization
Biological Processdendritic spine organization
Biological Processendocytosis
Biological Processestablishment of localization in cell
Biological Processflagellated sperm motility
Biological Processgeneration of ovulation cycle rhythm
Biological Processmemory
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-1 beta production
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of protein phosphorylation
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpositive regulation of amyloid-beta formation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of excitatory postsynaptic potential
Biological Processpositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
Biological Processpositive regulation of long-term synaptic potentiation
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processregulation of amyloid fibril formation
Biological Processregulation of norepinephrine secretion
Biological Processregulation of synapse structural plasticity
Biological Processregulation of synaptic transmission, dopaminergic
Biological Processresponse to amyloid-beta
Biological Processresponse to cold
Biological Processresponse to food
Biological Processsensory processing
Biological Processsynaptic transmission, cholinergic
Biological ProcessT cell activation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuronal acetylcholine receptor subunit alpha-7

Gene names

    • Name
      CHRNA7

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A337SQQ4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Postsynaptic cell membrane
; Multi-pass membrane protein
Synaptic cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane228-252Helical
Transmembrane259-277Helical
Transmembrane289-314Helical
Transmembrane467-487Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_502396510320-499Neuronal acetylcholine receptor subunit alpha-7

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-227Neurotransmitter-gated ion-channel ligand-binding
Domain234-483Neurotransmitter-gated ion-channel transmembrane

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    499
  • Mass (Da)
    56,203
  • Last updated
    2019-12-11 v2
  • Checksum
    EB75CF72A80CAB99
MRRSVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKTVRFPDGLIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSEKFYECCKEPYPDVTFTVTIRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVEMSAVAGPPTTNGNLLYIGFRGLDGVHCAPTPDSGVVCGRMACSPTHDEQLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337SU17A0A337SU17_FELCACHRNA7319

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04000441
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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