A0A337SQE3 · A0A337SQE3_FELCA
- ProteinProstaglandin G/H synthase 1
- GenePTGS1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids554 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2This reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- prostaglandin G2 + AH2 = prostaglandin H2 + A + H2OThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 161 | Proton acceptor | |||
Active site | 339 | For cyclooxygenase activity | |||
Binding site | 342 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Molecular Function | dioxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | peroxidase activity | |
Molecular Function | prostaglandin-endoperoxide synthase activity | |
Biological Process | prostaglandin biosynthetic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin G/H synthase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337SQE3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-26 | ||||
Chain | PRO_5016416313 | 27-554 | Prostaglandin G/H synthase 1 | ||
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length554
- Mass (Da)63,813
- Last updated2018-10-10 v1
- Checksum4A162D5CFD37F820
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M3WEM6 | M3WEM6_FELCA | PTGS1 | 602 | ||
A0A5F5XPV0 | A0A5F5XPV0_FELCA | PTGS1 | 285 | ||
A0A5F5Y1X5 | A0A5F5Y1X5_FELCA | PTGS1 | 563 | ||
A0A5F5XQU1 | A0A5F5XQU1_FELCA | PTGS1 | 633 | ||
A0A337SM80 | A0A337SM80_FELCA | PTGS1 | 339 | ||
A0A2I2V4W7 | A0A2I2V4W7_FELCA | PTGS1 | 350 | ||
A0A337SQR8 | A0A337SQR8_FELCA | PTGS1 | 332 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04004382 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |