A0A337SQE3 · A0A337SQE3_FELCA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2
    This reaction proceeds in the forward direction.
  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
    This reaction proceeds in the forward direction.
    EC:1.14.99.1 (UniProtKB | ENZYME | Rhea)
  • (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
    This reaction proceeds in the forward direction.
  • prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
    This reaction proceeds in the forward direction.

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site161Proton acceptor
Active site339For cyclooxygenase activity
Binding site342Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Molecular Functiondioxygenase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxidase activity
Molecular Functionprostaglandin-endoperoxide synthase activity
Biological Processprostaglandin biosynthetic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin G/H synthase 1
  • EC number
  • Alternative names
    • Cyclooxygenase-1
    • Prostaglandin H2 synthase 1
    • Prostaglandin-endoperoxide synthase 1

Gene names

    • Name
      PTGS1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A337SQE3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_501641631327-554Prostaglandin G/H synthase 1

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-72EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    554
  • Mass (Da)
    63,813
  • Last updated
    2018-10-10 v1
  • Checksum
    4A162D5CFD37F820
MSRRSRLLRFPLLLLLLLLQPPQVLPADSRAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPAFLHFLLTHGRWFWEFVNATFIRDMLMRLVLTGKKQLPDAQILGHRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLHGEMYPPSVEEAPVLMHYPRNIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNQLYHWHPLMPDSFKVGSREYSYEQFLFNTSMLVDYGVEALVDAFSRQSAGRIGGGRNMDHHVLHVAVDVIKESRELRLQPFNEYRKRFGLRPYTSFQELTGEKEMAAELEELYGDIDALEFFPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFHVPDPHQDDGPGVERPSTEL

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M3WEM6M3WEM6_FELCAPTGS1602
A0A5F5XPV0A0A5F5XPV0_FELCAPTGS1285
A0A5F5Y1X5A0A5F5Y1X5_FELCAPTGS1563
A0A5F5XQU1A0A5F5XQU1_FELCAPTGS1633
A0A337SM80A0A337SM80_FELCAPTGS1339
A0A2I2V4W7A0A2I2V4W7_FELCAPTGS1350
A0A337SQR8A0A337SQR8_FELCAPTGS1332

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04004382
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help