A0A337S564 · A0A337S564_FELCA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePLCB1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1216 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337S564
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 469-534 | Disordered | ||||
Sequence: KSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA | ||||||
Compositional bias | 480-500 | Polar residues | ||||
Sequence: KKLSEQASNTYSDSSSVFEPS | ||||||
Compositional bias | 507-521 | Acidic residues | ||||
Sequence: ADTESDDDDDDDDCK | ||||||
Domain | 540-656 | PI-PLC Y-box | ||||
Sequence: MSNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMR | ||||||
Domain | 656-784 | C2 | ||||
Sequence: RRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPL | ||||||
Region | 834-891 | Disordered | ||||
Sequence: DEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAP | ||||||
Compositional bias | 851-875 | Polar residues | ||||
Sequence: APSEARTTPAENGVNHTTSLAPKPP | ||||||
Compositional bias | 945-982 | Basic and acidic residues | ||||
Sequence: IKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSS | ||||||
Region | 945-995 | Disordered | ||||
Sequence: IKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLA | ||||||
Region | 1072-1095 | Disordered | ||||
Sequence: MDKKRQEKITEAKSKDKSQMEEEK | ||||||
Region | 1172-1216 | Disordered | ||||
Sequence: KISEDSNHSSAPPSLASDPGKLNHRPPSSEELEGDNPGKEFDTPL | ||||||
Compositional bias | 1195-1216 | Basic and acidic residues | ||||
Sequence: HRPPSSEELEGDNPGKEFDTPL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)138,580
- Last updated2018-10-10 v1
- Checksum69E181CBB4312504
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I2U959 | A0A2I2U959_FELCA | PLCB1 | 1173 | ||
A0A2I2UAJ4 | A0A2I2UAJ4_FELCA | PLCB1 | 1051 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 480-500 | Polar residues | ||||
Sequence: KKLSEQASNTYSDSSSVFEPS | ||||||
Compositional bias | 507-521 | Acidic residues | ||||
Sequence: ADTESDDDDDDDDCK | ||||||
Compositional bias | 851-875 | Polar residues | ||||
Sequence: APSEARTTPAENGVNHTTSLAPKPP | ||||||
Compositional bias | 945-982 | Basic and acidic residues | ||||
Sequence: IKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSS | ||||||
Compositional bias | 1195-1216 | Basic and acidic residues | ||||
Sequence: HRPPSSEELEGDNPGKEFDTPL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003379 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |