A0A337S491 · A0A337S491_FELCA

Function

function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Cellular Componentsarcoplasmic reticulum membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncalcium ion binding
Molecular FunctionP-type calcium transporter activity
Molecular Functionprotein homodimerization activity
Biological Processapoptotic mitochondrial changes
Biological Processcalcium ion import
Biological Processcalcium ion transmembrane transport
Biological Processintracellular calcium ion homeostasis
Biological Processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Processmaintenance of mitochondrion location
Biological Processnegative regulation of endoplasmic reticulum calcium ion concentration
Biological Processpositive regulation of endoplasmic reticulum calcium ion concentration
Biological Processpositive regulation of fast-twitch skeletal muscle fiber contraction
Biological Processpositive regulation of mitochondrial calcium ion concentration
Biological Processrelaxation of skeletal muscle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-transporting ATPase
  • EC number

Gene names

    • Name
      ATP2A1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A337S491

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Sarcoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-78Helical
Transmembrane84-107Helical
Transmembrane260-280Helical
Transmembrane292-321Helical
Transmembrane759-780Helical
Transmembrane832-856Helical
Transmembrane930-949Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with sarcolipin (SLN). Interacts with phospholamban (PLN). Interacts with myoregulin (MRLN). Interacts with DWORF. Interacts with VMP1.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain3-77Cation-transporting P-type ATPase N-terminal
Region998-1019Disordered
Compositional bias1000-1019Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,049
  • Mass (Da)
    115,673
  • Last updated
    2019-12-11 v1
  • Checksum
    94DD93714F1CAF1C
MEAAHSKTTEECLAYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKTVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWLRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGNICVLNEFSITGSTYAPEGEVLKNDKPVRSGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFSTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPITGPVKDKILSVIKEWGTGRDTLRCLALATRDTPPKREEMILDDSARFMEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYADDGPHVTYSQLTHFMKCNEENPDFEGLDCEVFEAPQPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDCTQWLMVLKISFPVILLDELLKFIARNYLEGKPRPPPRHPVRPWPHTAPPSALQRRLPPPPTLLSWVLWPLPRAPTPLHLCRHPQPP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I2U569A0A2I2U569_FELCAATP2A11000
A0A2I2V2N1A0A2I2V2N1_FELCAATP2A1993

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1000-1019Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04002788
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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