A0A337S491 · A0A337S491_FELCA
- ProteinCalcium-transporting ATPase
- GeneATP2A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1049 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Catalytic activity
- Ca2+(in) + ATP + H2O = Ca2+(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.Ca2+ (in)CHEBI:29108
+ CHEBI:30616 + CHEBI:15377 = Ca2+ (out)CHEBI:29108+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Cofactor
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-transporting ATPase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337S491
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Sarcoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 60-78 | Helical | |||
Transmembrane | 84-107 | Helical | |||
Transmembrane | 260-280 | Helical | |||
Transmembrane | 292-321 | Helical | |||
Transmembrane | 759-780 | Helical | |||
Transmembrane | 832-856 | Helical | |||
Transmembrane | 930-949 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with sarcolipin (SLN). Interacts with phospholamban (PLN). Interacts with myoregulin (MRLN). Interacts with DWORF. Interacts with VMP1.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-77 | Cation-transporting P-type ATPase N-terminal | |||
Region | 998-1019 | Disordered | |||
Compositional bias | 1000-1019 | Pro residues | |||
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,049
- Mass (Da)115,673
- Last updated2019-12-11 v1
- Checksum94DD93714F1CAF1C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I2U569 | A0A2I2U569_FELCA | ATP2A1 | 1000 | ||
A0A2I2V2N1 | A0A2I2V2N1_FELCA | ATP2A1 | 993 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1000-1019 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04002788 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |