A0A337RXY0 · A0A337RXY0_FELCA

Function

function

Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.

Catalytic activity

  • (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.232 (UniProtKB | ENZYME | Rhea)
  • 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H+ = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+
    This reaction proceeds in the forward direction.
  • prostaglandin A1 + NAD+ = 15-oxo-prostaglandin A1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E1 + NAD+ = 15-oxoprostaglandin E1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E2 + NAD+ = 15-oxoprostaglandin E2 + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.141 (UniProtKB | ENZYME | Rhea)
  • resolvin D1 + NAD+ = 17-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D1 + NAD+ = 8-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 16-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 7-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin E1 + NAD+ = 18-oxo-resolvin E1 + NADH + H+
    This reaction proceeds in the forward direction.
  • lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • EC number
  • Alternative names
    • Eicosanoid/docosanoid dehydrogenase [NAD(+)]
    • Prostaglandin dehydrogenase 1

Gene names

    • Name
      HPGD

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A337RXY0

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    21,527
  • Last updated
    2018-10-10 v1
  • Checksum
    3B446FEC2A02AFC5
MHVNGKVALVTGAAQGIGRAFAEALLHKGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFIQCDVADQEQLRGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMNSGVRLNAICPGFVNTPILESIEKEENMGQYIEYKDHIKDMMKFYGILDPSMIANGLITLIEDALNGAIMKITTSKGIHFQDYETTPFHAKTQ

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M3W2P7M3W2P7_FELCAHPGD265
A0A337RVI6A0A337RVI6_FELCAHPGD178
A0A337S4Z1A0A337S4Z1_FELCAHPGD143

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04001605
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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