A0A337RXY0 · A0A337RXY0_FELCA
- Protein15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- GeneHPGD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids197 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Catalytic activity
- (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H+This reaction proceeds in the forward direction.
- 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H+This reaction proceeds in the forward direction.
- 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H+ = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+This reaction proceeds in the forward direction.
- prostaglandin A1 + NAD+ = 15-oxo-prostaglandin A1 + NADH + H+This reaction proceeds in the forward direction.
- prostaglandin E1 + NAD+ = 15-oxoprostaglandin E1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D1 + NAD+ = 17-oxoresolvin D1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D1 + NAD+ = 8-oxoresolvin D1 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D2 + NAD+ = 16-oxoresolvin D2 + NADH + H+This reaction proceeds in the forward direction.
- resolvin D2 + NAD+ = 7-oxoresolvin D2 + NADH + H+This reaction proceeds in the forward direction.
- resolvin E1 + NAD+ = 18-oxo-resolvin E1 + NADH + H+This reaction proceeds in the forward direction.
- lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Biological Process | prostaglandin metabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337RXY0
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length197
- Mass (Da)21,527
- Last updated2018-10-10 v1
- Checksum3B446FEC2A02AFC5
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M3W2P7 | M3W2P7_FELCA | HPGD | 265 | ||
A0A337RVI6 | A0A337RVI6_FELCA | HPGD | 178 | ||
A0A337S4Z1 | A0A337S4Z1_FELCA | HPGD | 143 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04001605 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |