A0A337RXK1 · A0A337RXK1_FELCA
- ProteinArylsulfatase
- GeneSULF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids849 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 53 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 88 | Nucleophile | |||
Binding site | 88 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 317 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 318 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi stack | |
Molecular Function | calcium ion binding | |
Molecular Function | sulfuric ester hydrolase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArylsulfatase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337RXK1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5023899837 | 25-849 | Arylsulfatase | ||
Modified residue | 88 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-374 | Sulfatase N-terminal | |||
Domain | 529-663 | Extracellular sulfatase C-terminal | |||
Compositional bias | 547-579 | Basic and acidic residues | |||
Region | 547-590 | Disordered | |||
Coiled coil | 627-696 | ||||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length849
- Mass (Da)97,764
- Last updated2019-12-11 v1
- ChecksumCB9A6A23E7ECA414
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M3WLT7 | M3WLT7_FELCA | SULF2 | 869 | ||
A0A5F5XWT4 | A0A5F5XWT4_FELCA | SULF2 | 893 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 547-579 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003379 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |