A0A337RXI9 · A0A337RXI9_FELCA
- ProteinInsulin-like growth factor I
- GeneIGF1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids195 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameInsulin-like growth factor I
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A337RXI9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-48 | |||||
Sequence: MGKISSLPTQLFKCCFCDFLKVKMHIMSPSHLFYLGLCLLTFTSSATA | ||||||
Chain | PRO_5016269117 | 49-195 | Insulin-like growth factor I | |||
Sequence: GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKYHPPSTTKKTKSQRRRKGGPKKHPGGEQKVGTEASQQMKGKKKEQRRETGAREHRGKKGKW | ||||||
Disulfide bond | 54↔96 | |||||
Sequence: CGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECC | ||||||
Disulfide bond | 66↔109 | |||||
Sequence: CGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYC | ||||||
Disulfide bond | 95↔100 | |||||
Sequence: CCFRSC |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 51-109 | Insulin-like | ||||
Sequence: ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYC | ||||||
Region | 119-195 | Disordered | ||||
Sequence: RSVRAQRHTDMPKAQKYHPPSTTKKTKSQRRRKGGPKKHPGGEQKVGTEASQQMKGKKKEQRRETGAREHRGKKGKW | ||||||
Compositional bias | 141-156 | Basic residues | ||||
Sequence: TKKTKSQRRRKGGPKK | ||||||
Compositional bias | 170-189 | Basic and acidic residues | ||||
Sequence: QQMKGKKKEQRRETGAREHR |
Sequence similarities
Belongs to the insulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length195
- Mass (Da)21,865
- Last updated2018-10-10 v1
- Checksum09F1083D4409A336
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I2UIQ7 | A0A2I2UIQ7_FELCA | IGF1 | 159 | ||
A0A2I2UWS2 | A0A2I2UWS2_FELCA | IGF1 | 153 | ||
M3XDZ9 | M3XDZ9_FELCA | IGF1 | 143 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 141-156 | Basic residues | ||||
Sequence: TKKTKSQRRRKGGPKK | ||||||
Compositional bias | 170-189 | Basic and acidic residues | ||||
Sequence: QQMKGKKKEQRRETGAREHR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003655 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |