A0A336MLG8 · A0A336MLG8_CULSO
- ProteinATP-binding cassette sub-family B member 6
- GeneCSON002424
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids840 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O + heme b(in) = ADP + H+ + heme b(out) + phosphateThis reaction proceeds in the forward direction.
CHEBI:30616 + CHEBI:15377 + heme b (in)CHEBI:60344= CHEBI:456216 + CHEBI:15378 + heme b (out)CHEBI:60344+ CHEBI:43474 - ATP + H2O + pheophorbide a(in) = ADP + H+ + pheophorbide a(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + protoporphyrin IX(in) = ADP + H+ + phosphate + protoporphyrin IX(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin I(in) = ADP + H+ + phosphate + uroporphyrin I(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin III(in) = ADP + H+ + phosphate + uroporphyrin III(out)This reaction proceeds in the forward direction.
- ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Ceratopogonidae > Ceratopogoninae > Culicoides > Monoculicoides
Accessions
- Primary accessionA0A336MLG8
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 29-48 | Helical | ||||
Sequence: ISSSVLFGFIFLFGTIELFF | ||||||
Transmembrane | 69-91 | Helical | ||||
Sequence: FQIFLIFVILVFTIVRFILQGFV | ||||||
Transmembrane | 97-116 | Helical | ||||
Sequence: IYGFMIMSLCFTVIGYMFSW | ||||||
Transmembrane | 137-155 | Helical | ||||
Sequence: LVLLVFWTLAFATQNLVFI | ||||||
Transmembrane | 175-193 | Helical | ||||
Sequence: MGLFIGRYITTFLIFVIGL | ||||||
Transmembrane | 246-266 | Helical | ||||
Sequence: VIFCFVLLLAGRIINVYVPVY | ||||||
Transmembrane | 363-385 | Helical | ||||
Sequence: LLNYILFSITPTIVDILIAVVFF | ||||||
Transmembrane | 391-412 | Helical | ||||
Sequence: IWFGLIVFATMTLYIIATITVT | ||||||
Transmembrane | 483-502 | Helical | ||||
Sequence: VIVCAGLLAGSLLCAWMVYA | ||||||
Transmembrane | 514-535 | Helical | ||||
Sequence: FSSYLIQLYVPLNWFGTFYRAI |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 247-537 | ABC transmembrane type-1 | ||||
Sequence: IFCFVLLLAGRIINVYVPVYNKKIVDSLSEPNPSFRWDWILLYVGMKFLQGGGTGSMGVLNNLRSFLWIRIQQYTTREIELELFAHLHNLSLRWHLNRKTGEVLRIMDRGTDSITNLLNYILFSITPTIVDILIAVVFFVTVFNIWFGLIVFATMTLYIIATITVTEWRTKFQRRMNLADNAQKARSVDSLLNFETVKYYGAEKYEVECYREAILNYQKEEWNSSVTLNILNTVQNVIVCAGLLAGSLLCAWMVYAQKGLTVGDYVLFSSYLIQLYVPLNWFGTFYRAIQK | ||||||
Domain | 571-805 | ABC transporter | ||||
Sequence: VDFSNVTFGYTPDRFVLKNVSFTVPAGKTVALVGPSGAGKSTIIRLLFRFYDVDSGAIMIDGQNIKTVTQQSLRKSIGVVPQDTVLFNNTIKYNIQYGRVDAPEADVLTASRSADIHEKILSFPDKYETQVGERGLRLSGGEKQRVAIARTILKSPFIVLLDEATSALDTQTERNIQTALQKVCTNRTTIIVAHRLSTIIHADEILVLKDGVIAERGRHDQLLLSQGLYYDMWNQ | ||||||
Compositional bias | 812-831 | Polar residues | ||||
Sequence: SQDNTTEDQVQANGELRQNN | ||||||
Region | 812-840 | Disordered | ||||
Sequence: SQDNTTEDQVQANGELRQNNEIPRNHYHN |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length840
- Mass (Da)96,629
- Last updated2018-10-10 v1
- ChecksumBC06AE0FC98F5C43
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 812-831 | Polar residues | ||||
Sequence: SQDNTTEDQVQANGELRQNN |