A0A332M038 · A0A332M038_KLEPN

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-14substrate
Binding site40-44substrate
Binding site142substrate
Binding site186ATP (UniProtKB | ChEBI)
Binding site222-227ATP (UniProtKB | ChEBI)
Binding site248K+ (UniProtKB | ChEBI)
Binding site250K+ (UniProtKB | ChEBI)
Binding site253-254ATP (UniProtKB | ChEBI)
Active site254Proton acceptor
Binding site254substrate
Binding site284K+ (UniProtKB | ChEBI)
Binding site287K+ (UniProtKB | ChEBI)
Binding site289K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionribokinase activity
Biological ProcessD-ribose catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      rbsK_1
    • Synonyms
      rbsK
    • ORF names
      FME62_17335
      , SAMEA4364603_02062

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 4300STDY6470422
    • EN5275
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A332M038

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-292Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
Belongs to the carbohydrate kinase pfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    313
  • Mass (Da)
    32,139
  • Last updated
    2018-10-10 v1
  • Checksum
    6DED521E272D81A4
MSGKVCVFGSFNFDMVARVDRFPVPGESLVACGSMTSAGGKGANQATAALKAGANVHYIGKIGNDTFGHFARRHLKGVGFNAVTLLVAEEIPTGNALIYVAGNDAENMIAVDPGANMTVTDDEIAGCIPAIGCADVVLVQLENNLSAIEQVIDAGKQAGALVILNPAPWQPVEHAVLSKVDLLTPNATEAGLMTGRRVDSLTAAAEAADVLHAQGARNVIITLGASGALLSELGVKSRVPCFPSHPRDTTGAGDAFNGALAARLACGEPLQAAARFAAAYAAVSVEKQGASSLPEYLEAQERLLRAAADYEMA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VINI01000014
EMBL· GenBank· DDBJ
MSS32527.1
EMBL· GenBank· DDBJ
Genomic DNA
UFEU01000005
EMBL· GenBank· DDBJ
SSK31115.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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