A0A329VHG6 · A0A329VHG6_9GAMM
- ProteinXanthine-guanine phosphoribosyltransferase
- Genegpt
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids153 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Catalytic activity
- GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate
- IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Cofactor
Pathway
Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 37-38 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 69 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 69 | GMP (UniProtKB | ChEBI) | |||
Binding site | 88-96 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | |||
Binding site | 89 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 92 | guanine (UniProtKB | ChEBI) | |||
Binding site | 92 | xanthine (UniProtKB | ChEBI) | |||
Binding site | 92-96 | GMP (UniProtKB | ChEBI) | |||
Binding site | 134-135 | GMP (UniProtKB | ChEBI) | |||
Binding site | 135 | guanine (UniProtKB | ChEBI) | |||
Binding site | 135 | xanthine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | xanthine phosphoribosyltransferase activity | |
Biological Process | GMP salvage | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage | |
Biological Process | XMP salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameXanthine-guanine phosphoribosyltransferase
- EC number
- Short namesXGPRT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Morganellaceae > Photorhabdus
Accessions
- Primary accessionA0A329VHG6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length153
- Mass (Da)17,063
- Last updated2018-10-10 v1
- ChecksumE2FA5FB134CA9836
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NSCI01000007 EMBL· GenBank· DDBJ | RAW91666.1 EMBL· GenBank· DDBJ | Genomic DNA |