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A0A328UEJ3 · A0A328UEJ3_9FIRM

Function

function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site201Zn2+ (UniProtKB | ChEBI)
Binding site264Zn2+ (UniProtKB | ChEBI)
Binding site265Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase

Gene names

    • ORF names
      DPQ25_01985

Organism names

Accessions

  • Primary accession
    A0A328UEJ3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-279Hcy-binding
Domain307-551Pterin-binding
Domain571-664B12-binding N-terminal
Domain667-786B12-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    786
  • Mass (Da)
    84,426
  • Last updated
    2018-10-10 v1
  • MD5 Checksum
    50B1C1F83C398A81C88301A29C47B66C
MLNLLNKIILLDGAMGTMLQASGAELGKVPEALNLTQPELIQSIHRQYVEAGADIIYSNTFGANRRKLQHCSHSVEALITAGVQNARAAAKGSETMVALSCGPIGALLEPNGSLKMEEAYDIFREMMTIGERAGADLIVCETITDLLEMKAAVLAAKENTRLPVFCTMSFEANGHTFTGTGLASMALTLEGLGADALGINCSLGPDEILPLVQELVQWTSLPIIVKPNAGLPNLNSNAYDISAEDFCTRMEGFLELGATIIGGCCGTTPAYIRLLAESYKGRAPVLRHSRRQAALCSATKAVVVDGVRVVGERINPTGKKLFKEALRNRNIDYILTQAIEQVNAGAEILDVNVGLPGIDEVDMMSETVRELQGVVDAPLQLDSSSPAVLERGLRLYSGKALVNSVNGERSVLDKILPLVKKYGAAVIGLTLDEKGIPNQAEERFKIAERIVEAARQYGIPQEDLYIDCLTLTASVQQAEVRETLRAVQMVKERLGVKTVLGVSNISFGLPEREIINTAFLTLALAHGLDLPIINPNNRAMMNAVDAFNVLYNRDTGAGRYLERHAANPEKSPSAAPNATGYPSLEQAVRDGLKDYARTATQELLKTQDPMHIVNDLLIPALDQVGNDFETGKLFLPQLIQAATAAQAGFDEIKKNLAGNRQGQAISKGKIILATVKGDIHDIGKNIVKVILENYGYDIIDLGRDVPPETVVLEVNRSGAKLVGLSALMTTTVANMALTIQALRRETNCTIMVGGAVLTESYAKEIGADYYAKDAKASADIAKIVLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QLYR01000001
EMBL· GenBank· DDBJ
RAQ30297.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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