A0A328L519 · A0A328L519_9BACI

  • Protein
    Malonate-semialdehyde dehydrogenase
  • Gene
    iolA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. Is involved in a myo-inositol catabolic pathway. Bicarbonate, and not CO2, is the end-product of the enzymatic reaction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site155NAD+ (UniProtKB | ChEBI)
Binding site179NAD+ (UniProtKB | ChEBI)
Binding site182NAD+ (UniProtKB | ChEBI)
Binding site183NAD+ (UniProtKB | ChEBI)
Active site287Nucleophile
Binding site387NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmalonate-semialdehyde dehydrogenase (acetylating) activity
Molecular Functionmethylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Biological Processinositol catabolic process
Biological Processthymine catabolic process
Biological Processvaline catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malonate-semialdehyde dehydrogenase
  • EC number
  • Short names
    MSA dehydrogenase
  • Alternative names
    • Methylmalonate semialdehyde dehydrogenase
      (MMSA dehydrogenase
      ; MSDH
      )

Gene names

    • Name
      iolA
    • ORF names
      B5P42_29820

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SRB_331
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0A328L519

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-481Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    486
  • Mass (Da)
    53,124
  • Last updated
    2018-10-10 v1
  • Checksum
    5D384338F26BB484
MVVMKNVQTLKNYIGGQWIESTSKQVEDVPNPATGEIIARVPLSTKEDLDRAVATAKEAFKTWRKVAVPRRARILFRYQQLLIENWEELAKLVTLENGKSYKEAYGEVQRGIECVEFAAGAPTLMMGEQLPDIATGVESGMYRYPIGVIAGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPLLANRIAELFKEAGLPDGVLNIVHGAHDVVNGILDNEDVKAVSFVGSQPVAEYIYKTAAANGKRVQALAGAKNHSIVLKDADLSSTVKEITSAAFGSAGERCMAAAVVVVEEDVADELVNRLLQEANAITIGNGLEEGVFLGPVIREGHKERTLGYIQSGVEQGATLIRDGREDDVANSQGYFVGPTIFDNVTQEMKIWQDEIFAPVLSIVRVKDLMEAIHVANASPFANGACLYTNSAKAIREFREEIDAGMLGVNLGVPAPMAFFPFSGYKKSFYGDLHANGKDGVEFYTRKKMLTARY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NADV01000071
EMBL· GenBank· DDBJ
RAN71895.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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